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Our results reveal that only CD105 expression was down-regulated in all four cases of differentiation into osteoblasts, chondrocytes, adipocytes, and respiratory epithelial cells. The percentage of CD105-positive Angiotensin 1/2 (1-5) was significantly decreased in osteoblasts (3.5 ± 1.4%), chondrocytes (3.5 ± 2.3%), adipocytes (16.7 ± 3.6%), and respiratory epithelium (2.1 ± 1.5%) following differentiation of UCB-MSCs (P cells following adipogenic differentiation less decreased than those following osteogenic, chondrogenic, and respiratory epithelial differentiation, which might be associated with lower capacity for adipogenic differentiation of UCB-MSCs [20] and [21].