In conclusion, our study provide evidences for generation of RGC-like AT 9283 from ES cell derived neural progenitors which will have immense importance in cell replacement therapy for treating neurodegenerative diseases like, glaucoma.
Acknowledgments
This work was supported by Grants from Dept. of Science & Technology and Dept. of Biotechnology, Govt. of India to J.J.; R.S, C.L.I. and M.S.D. were supported by research fellowships from CSIR & ICMR, Govt. of India.
Appendix A. Supplementary data
Supplementary material. Help with DOC filesOptionsDownload file ( K)
Keywords
Glioblastoma; SirT1; CD133; Radiotherapy
In this study, we isolated CD133-positive cells from GBM tissues, and this GBM-CD133+ population displayed higher levels of SirT1 expression. Knock-down of SirT1 expression in CD133+ cells enhanced the ability of radiotherapy to inhibit tumor invasion, colony formation and self-renewal. Survival analysis further demonstrated that the mean survival rate of mice with CD133+ tumors under radiation treatment was significantly improved by knock-down of SirT1. These results suggested that the resistance of GBM-CD133+ to radiotherapy is partially due to preferential activation of SirT1 gene expression.
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