Personally, I'm really looking forward to this episode. I've been wondering for a while about the nature of a God-like deity in the Supernatural verse and I know a few other people have too. (And, when I say 'God' I mean the Judeo-Christian god.) While the exorcisms the boys have down are primarily latin and Christian in nature, the demonology of the show doesn't seem to be strongly influenced one way or the other. Furthermore, entities like Reapers haven't been played as either good or evil - simply natural, not necessarily and 'Angel of Death' or anything like that. I'm really interested to see, world-wise, where the episode goes. After all, we know that true evil exists in the Supernatural world, but true good is still up in the air.
Also (WARNING, HERE BE SPOILERS ABOUT THE DIRECTORS CUTS), I'm really keen on what this division of faith with Sam praying and Dean 'Absolutely Definitely Not' will mean for the boys and what kind of consequences that might have in the run of this episode. Buuut, I'll go ahead and shut up nauw so I don't get too theoretical and hypothetical on y'all without any context. xD