Cyclin-dependent kinases (CDKs) and cyclins play critical roles in
Doxazosin Mesylate regulation [15] and [16]. Many anti-cancer agents derived from natural products exhibit growth inhibitory activity in carcinoma cells through cell cycle regulation. For instance, paclitaxel inhibits microtubule disassembly, and butyrolactone inhibits CDK activity; both cause cell cycle arrest at the G2/M phase [17] and [18]. Antofine, a tylophorine analogue, arrests the cell cycle at the G2/M phase in Col2, human colon cancer cells [19]. DCB3500 (tylophorine) and DCB3503 (a tylophorine analogue) cause S-phase accumulation of KB cells but have no effect on specific
cell cycle arrest in HepG2 cells [8]. DCB3503’s effect on cell cycle progression was further examined in PANC-1 cells [13] and was suggested to be through downregulated cell cycle regulatory proteins. However, more information on specific interactions and relations is needed to elucidate substantial links between phenanthroindolizidine alkaloids and anti-cancer-cell growth and cell cycle interference.
