Conclusions
We synthesized NIR imaging agent YC-27 3 in reasonable yield using mild, well established conditions. Because of its salutary pharmacokinetics in vivo, YC-27 3 CT99021 promising for clinical investigation of PSMA-expressing tissue, such as prostate tumors or solid tumor neovasculature.
Acknowledgments
We thank Dr. David Wasserman of LI-COR Biosciences for use of their equipment and guidance in the in vivo study. We thank Gilbert Green for expert assistance. We also thank U24 CA92871 and R01 CA134675.
Appendix A. Supplementary data
Supplementary data.
Absorption and emision spectra of YC-27 3 in water.
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Keywords
Acute-on-chronic liver failure; Hepatitis B; Toll-like receptor 3; Dendritic cell; Interferon-β
Introduction
Hepatitis B virus (HBV) infection has become one of the most serious public health threats in recent years. Two billion people worldwide have been infected with HBV, and more that 350 million have become victims of chronic HBV infection [1]. Chronic infection in some patients may progress rapidly towards liver failure, a condition referred to as acute-on-chronic hepatitis B liver failure (ACHBLF) [2].
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