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Table 2.
The junction parameters Jtwist and Jroll for sticky end structure and other junction structures.
SequenceJtwist (°)Jroll (°)PDB ID [reference]
d(CGGCGGCCGC)444.6149.8This work
d(CCGGTACCGG)439.2153.61DCW [7]
d(CCGGTACCGG)439.0159.11JUC [25]
d(CCGGTACCGG)441.0153.21ZEZ [26]
d(CCGGCGCCGG)438.0155.51P4Y [12]
d(TCGGTACCGA)439.0154.61L4J [27]
d(TCGGTACCGA)441.2161.21M6G [27]
d(CCGGGACCGG)440.0170.2467D [6]
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The significance of this AZD7762 study is that, based on lessons learned from the packing of molecules in crystals of DNA oligonucleotides, a simple sequence was designed to self-assemble and form a structure of potential use in nanotechnology. The design may be varied to create, for example, lattices with larges pores. Fig. 4 shows the model of a rhombus with twenty base-pairs (or two helical turns) to a side. The length of the each side is now 64.6 ? and it encloses a cavity of area 2894.1 ?2.
Fig. 4.
Model of a rhombus that has 20 base-pairs to a side, forming cavities of size 29 nm2.