I absolutely adore it, and I never miss a Friday, not if I can help it. (So far, I haven't had to.)
The characters are cleverly written and beautifully portrayed, and I love the dynamics between the actors. All of the actors have really great chemistry and they mesh together so well that for all of an hour, I believe David Krumholtz and Rob Morrow are really brothers, and Judd Hirsch is definitely their dad. Peter MacNicol was made to play a quirky physics professor.
The math aspect is an interesting touch; it's really cool to see things through a different perspective, especially one that so utterly and completely goes over my head. My brain is not compatiable with math. I failed algebra twice and it takes me minutes to do simple math in my head. So believe me when I say that when Charlie goes into CharlieVision mode to visually explain what he's talking about, it makes my life so much easier. whee