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2.6. Drug loading and in vitro release
Loading capacity = Wt/W0
Table 1.
DOX loading capacity of polymer capsules.
Feed ratio of DOX to polymer capsules (weight) Loading capacity (%)
PAA capsules PAA-PPEGA capsules
0.1 9.43 5.62
0.2 17.57 9.86
0.5 36.74 18.33
1 50.21 28.80
10 52.24 36.74
Table options
(Wt = Weight of drug in capsules; W0 = Weight of dried capsules).
In the in vitro pH controlled drug release experiment, the freezing dried DOX loaded PAA-PPEGA Pelitinib powder (10 mg) was dispersed in 10 mL of deionized water. The dispersion was transferred into a dialysis bag with the cut off molecular weight of 8000 g mol−1), followed by immersing the bag into 100 mL PBS buffer of pH 2.0 and 6.8 at room temperature with magnetic stirring. The amount of released drug was measured by a UV–vis spectrophotometer at 480 nm.
For the biodegradable controlled drug release experiment, the DOX loaded PAA-PPEGA capsule powder (10 mg) was dispersed into 10 mL of deionized water with the addition of DTT (1 mg) the resulting mixture was transferred into a dialysis bag (cut off molecular weight: 8000 g mol−1), followed by immersing the bag into 100 mL PBS buffer. The amount of released drug was measured by a UV–vis spectrophotometer at 480 nm.