Fe2O3 magnetic nanoparticles (MNP) of 43 nm diameter were coated with the thermoresponsive GSK1120212 poly-n-isopropylacrylamide and then loaded with DOX [73]. In vivo magnetic targeting of DOX-loaded MNP to Buffalo rat hepatocellular carcinoma was validated by MRI and histology, in conjunction with in vitro evidence for hyperthermia-induced DOX release, supporting possible future applications in multi-modal treatment of cancer.
Mesocrystalline CaCO3 particles encapsulating DOX, Au-DNA, and magnetite nanoparticles were synthesized as stage 1 microparticles (S1MPs), intended to marginate to vascular walls, after which the Au-DNA nanoparticles (stage 2 nanoparticles; S2NPs) and DOX would be released from S1MPs [74]. In a mouse tumor model, the targeted delivery of S2NPs into tumors was 10-fold more efficient than that of the nanoparticles themselves, with DOX being widely distributed in tumor slices.
Paclitaxel-loaded, superparamagnetic magnetite- and quantum dot-embedded polystyrene nanoparticles were conjugated to anti-prostate specific membrane antigen (anti-PSMA) antibodies [75]. Following i.v. injection into tumor-bearing nude mice, significant differences in fluorescent signals were observed between tumor regions treated with the PSMA-targeted nanocarrier system and the non-targeted nanocarrier system.
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Distribution patterns Although both species are considered
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