1. In a fight in closed spaces? Mustang. There aren't a lot of people who can outfight the Flame Alchemist in such circumstances I expect.
2. In a war zone? Mustang for the same reason, but they are even better as a team, so it'd be a shame to see them go into battle any other way. Poor Hughes!
3. On a date? Hughes. Less broody, more fun. I don't go for the lady-killer types.
4. At driving Ed crazy? Mustang. He owes him.
5. At manipulating others? Hughes is probably better at this than Mustang, even if we seldom see him properly in action in the series; I think this is a large part of what he does
for Mustang, though.
6. And in your own opinion? *sigh* Hughes. I almost stopped watching when he... left the first series.