About

Wesker made his first appearance as a non-playable character in the original Resident Evil game, assisting the player character against Lisa Trevor in the remake. In that game, he is the commanding officer of Special Tactics And Rescue Service (STARS) and leader of the Alpha team. It is eventually revealed that Wesker is a double agent working for the Umbrella Corporation; ordered by his superiors to lure the STARS into the Spencer mansion to be used as test subjects against the mutated creatures to gather battle data. Chris Redfield, Jill Valentine and the others come to learn of Wesker's true motive, but after releasing the Tyrant monster, Wesker seemingly dies.

But this is part of an even bigger plan. In the special giveaway fictional documentary titled Wesker's Report, Wesker reveals that he survived his apparent death in the first game by injecting himself beforehand with an experimental virus, provided by his former Umbrella colleague William Birkin, that revived and augmented him with superhuman strength, speed and regeneration, but at the expense of his humanity. Wesker returned in Resident Evil Code: Veronica, augmented with superhuman powers and working for an unnamed secret organization against Umbrella. When Chris knocks his sunglasses off during a brief struggle, Wesker's cat-like eyes are seen for the first time. He confronts both Chris and Alexia and he took the corpse of Steve Burnside for tests. In the remake, Code: Veronica X, he briefly confronts Chris' younger sister Claire and nearly kills her in order to torment Chris, but is called away by his associates and thus chooses to spare her life.

Wesker then appeared alongside William Birkin in Resident Evil Zero, a prequel to the original game, and later in Resident Evil 4 as a conspirator manipulating events from behind the scenes, where he would issue orders to Ada Wong. He is also a central character in Resident Evil: The Umbrella Chronicles and a playable character in several of the game's scenarios, expanding upon events alluded to in early games, as well as his involvement in Umbrella's downfall after the events of Code: Veronica and his development in Resident Evil 4. In the end he kills Sergei Vladimir, a loyal Umbrella enforcer.

Wesker returns in Resident Evil 5 as the main antagonist conspiring with Tricell Pharmaceutical Company to create a potent virus called Uroboros which he ultimately plans to release into the Earth's atmosphere, ensuring complete global saturation. Spencer reveals that Wesker was the survivor of a genetic engineering experiment on children - Project Wesker; Wesker(it is implied in the RE5 DLC "Lost In Nightmares" that another Wesker, Alex, survived as well). He then kills a frail Spencer. Chris and Sheva Alomar prevent the worldwide infection and ultimately kill Wesker inside a volcano at the end of the game. Masachika Kawata, the game's producer, confirmed that Wesker perished in the game's finale.[3] However, despite Kawata's claim Wesker had perished, a recent 15th anniversary special video supports that Wesker may still be alive as Wesker quotes that "Things are just warming up".[4]

Meanwhile, Wesker will make an appearance in the upcoming prequel Resident Evil: The Mercenaries 3D as a playable character with Jill Valentine.[5] Masachika Kawata, the game's producer, confirmed Wesker will return.[6]

Wesker appears in the crossover fighting game Marvel vs. Capcom 3: Fate of Two Worlds as a playable character and a key character in the game's plot, in which he joins forces with Doctor Doom as the two build an army of supervillains, attempting to merge the two dimensions in the hopes of conquering both.[7] In his ending, he captures many of the heroes who were fighting Galactus and uses them as test subjects for his Uroboros project (which is an indirect reference to the Marvel Zombies comics).

Wesker also makes a guest appearance as an unlockable skin in Lost Planet 2.