Pharmacological authorities

Pharmacodynamics.

Amoxicillin is a completely synthetic antibiotic with a wide range of antibacterial activity, which prevents gram-positive and gram-negative microorganisms. Amoxicillin is sensitive to β-lactamase and is associated with a drop in energy, because the activity spectrum of amoxicillin does not include microorganisms that synthesize the enzyme. Clavulanic acid has a β-lactam structure, is suitable for penalties, as well as greater inactivity of β-lactam enzymes, a powerful microorganism, and is resistant to penicillin and cephalosporins. Zokrem, there’s won’t be more active than the most important clinically important points of plasmid β-lactamase, as well as often go for the most extreme resistance to antibiotics.

click here Mikroorganizm, lower than that, the classification is more sensitive to amoxicillin / clavulanate in vitro.

Grampozitivnі aerobi: Bacillus anthracis, Enterococcus faecalis, Listeria monocytogenes, Nocardia asteroids, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus viridans INSHI β-gemolіtichnі VD Streptococcus, Staphylococcus aureus (metitsilіnchutlivі strains), Staphylococcus saprophyticus (metitsilіnchutlivі strains) koagulazonegativnі stafіlokoki ( metitsilіnchutlivі shtami).

Gramnegative aerobi: Bordetella pertussis, Haemophilus influenza, Haemophilus parainfluenzae, Helicobacter pylori, Moraxella catarrhalis, Neisseria gonorrhoeae, Pasteurella multocida, Vibrio cholerara.

Інші: Borrelia burgdorferi, Leptospirosa ictterohaemorrhagiae, Treponema pallidum.

Grampositive anaerobi: see Clostridium, Peptococcus niger, Peptostreptococcus magnus, Peptostreptococcus micros, see Peptostreptococcus.

Gram-negative anaerobi: see Bacteroides (including Bacteroides fragilis), see Capnocytophaga, Eikenella corrodens, see Fusobacterium, see Porphyromonas, see Prevotella.

With shtami z moglivoy nabutoyu resistance

Gram-negative aerobi: Escherichia coli, Klebsiella oxytoca, Klesiella pneumonia, see Klebsiella, Proteus mirabilis, Proteus vulgaris, see Proteus, see Salmonella, see Shigella.

Grampositive aerobi: see Corynebacterium, Enterococcus faecium.

Gram-negative aerobi: see Acinetobacter, Citrobacter freundii, see Enterobacter, Hafnia alvei, Legionella pneumophila, Morganella morganii, see Providencia, see Pseudomonas, see Serratia, Stenotrophomas maltophilia, Yesinia enterolitica.

Інші: Chlamydia pneumonia, Chlamydia psittaci, see Chlamydia, Coxiella burnetti, see Mycoplasma.

Pharmacokinetics.

Pharmacokinetic parameters of two components Augmented well received. The peak concentration in the bloodstream of both components is reached after approximately 1 year after oral administration of the drug. The optimal absorption rate is reached, so take the drug on the cob I will take it.

Dosage augmentinu zbіlshuі riven the drug in syrovattsі blood approximately doubled.

Offending the components of the drug, such as clavulanate and amoxicillin, may have a low level of sound with blood syrups, approximately 70% of them will be insulted from blood pressure from an unrelated patient.

Causes and Risk Factors

The causative agents of otitis media are usually streptococci, staphylococci, pneumococci, hemophilus influenzae, moraxella, influenza and parainfluenza viruses, adeno- and rhinoviruses. Less commonly, infectious agents are Proteus, Corynebacterium diphtheria, and microscopic fungi. The penetration of the pathogen into the tympanic cavity usually occurs through the Eustachian tube (by the pathogen), i.e. from the nasopharynx - for this reason, otitis media often becomes a complication of upper respiratory tract infections. In some cases, the pathogen enters the middle ear through a damaged eardrum (transtimpanic pathway) or with a blood stream for infectious diseases (measles, scarlet fever, tuberculosis, etc.).

Vaccination against pneumococcal infection and influenza helps to reduce the incidence and severity of otitis media in children.

Risk factors include:

• acute respiratory infections;
• immunodeficiency conditions;
• neoplasms of the nasal cavity and pharynx;
• endocrine disorders;
• allergy;
• anatomical features of the structure of the ear;
• eardrum injuries;
• ingress of amniotic fluid into the middle ear of the child during passage through the birth canal;
• getting into the ear of a foreign body;
• sudden changes in atmospheric pressure;
• hypothermia of the body;
• bad habits;
• poor nutrition;
• irrational use of antibacterial drugs.

Ecoclave (Amoxicillin Clavulanic acid) tablets 500 mg 125 mg, 15 pcs.: Indications

Infectious diseases of the upper (acute and chronic sinusitis, acute and chronic otitis media, pharyngeal abscess, tonsilopharyngitis) and lower respiratory tract (acute and chronic bronchitis, pneumonia, pleural empyema); urinary tract infections (including cystitis, urethritis, pyelonephritis), gynecological infections (including salpingitis, salpingoophoritis, endometritis, septic abortion, pelvioperitonitis); bile ducts (cholecystitis, cholangitis), bone and connective tissue (including chronic osteomyelitis), skin and soft tissues (phlegmon, wound infection), odontogenic infections (periodontitis); sexually transmitted infections (gonorrhea, chancroid).