Video recording of a microscopic field that follows the lysis of target RPMI8226 SB939 (large cells) over four hours by ex vivo-expanded γδT cells (small cells) at a 10:1 E/T ratio.
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Keywords
Brain cholesterol; Lipid–protein interaction; Serotonin1A receptor; Smith–Lemli–Opitz Syndrome
Fig. 1.
Chemical structure and membrane orientation of cholesterol. Three structurally distinct regions are shown as shaded boxes in (a): the 3β-hydroxyl group, the rigid steroid ring, and the flexible alkyl chain. The 3β-hydroxyl moiety is the only polar group in these sterols thereby contributing to their amphiphilic character and helps to orient and anchor them in the membrane. (b) The schematic orientation of cholesterol in relation to a phospholipid molecule in a lipid bilayer. The rigid and near planar steroid ring contributes to the ordering effect of cholesterol in phospholipid bilayers due to the restriction in motion imposed by it to adjacent phospholipid fatty acyl chains. The flexible alkyl chain extends into the hydrophobic core of the membrane. Modified from [4].
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SRNOMe a All tabulated values are the average values
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