Human fecal microflora in subjects with and without CAG
Fig. 3.
Effect of chronic atrophic gastritis (CAG) on human fecal microflora. The fecal bacterial populations of the two groups of subjects with and without CAG were compared by analyzing bacterial DNA extracted from fecal samples of 22 age- and sex-matched asymptomatic subjects by real-time quantitative PCR as described in Materials and methods. Comparisons of the populations of each of the 12 Terazosin or groups of bacteria are shown. ?p = 0.003, ??p = 0.002.
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Discussion
The gastrointestinal tract microflora is considered to be under the control of the gastric acid barrier, and bacterial overgrowth frequently occurs in the upper gastrointestinal tract under conditions characterized by reduced gastric acid secretion [3], [4], [5], [6] and [7]. However, little is known about the microflora of the lower intestine with gastric pathology and medications that lead to failure of the gastric acid barrier; there are few reports indicating an increase in the total number of bacterial counts in gastrectomized rats, and limited analyses using anaerobic culture methods [17] and [18]. This study is the first to report the results of molecular analysis for this issue.
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