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Discussion
Results presented in the study show that TCTP is a heat-inducible protein that can protect Dorsomorphin from thermal shock by potentially acting as a molecular chaperone. Our studies also show that overexpression of TCTP in cells can protect the cells from heat shock. These findings collectively suggest that TCTP may be a novel small molecular weight heat shock protein.
Expression of TCTP is known to be highly regulated, especially in response to a wide range of stress conditions such as ammonium starvation in fission yeast [9], in response to environmental pollutants such as dioxin in mouse embryonic cells [19], hypoxia conditions [20], DTT-induced oxidative stress [9], calcium perturbation [21], heavy metal toxicity [10] and heat shock [12]. In addition, one of the TCTP sequences deposited in the GenBank designates the protein as a pO2 related protein in the hepato-carcinoma cells (GenBank Accession No.: AAM51565). These reports collectively support the notion that TCTP may be a stress-related protein.