Some patients are intolerant of statins because of myalgia, myopathy, neuropathy or abnormal liver function tests. In such patients, lipid lowering can be achieved with alternative drugs, e.g. fibrates, niacin or cholesterol KU-60019 inhibitors. However, their efficacy in reducing stroke risk has not been shown conclusively [2].
6. Anti-hypertensive treatment
Hypertension is one of the best established risk-factors for first and recurrent stroke, and lowering blood pressure reduces stroke risk. This applies both to hypertensive and normotensive patients, and generally the recommendation for blood pressure treatment following a cerebrovascular event is to try and lower blood pressure as much as possible and as tolerated, as this will provide maximum protection. There is no clear target blood pressure, but benefit is seen with a reduction of 10/5 mmHg, and British Guidelines suggest aiming for a blood pressure of 130/80 mmHg [1] and [2]. Until recently, the drug class was thought to be of secondary importance, as long as satisfactory blood pressure lowering could be achieved.
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Such low level of genetic differentiation
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