The prevalence of migraine is according to the recently published American Migraine Prevalence and Prevention study 17% in women and 6% in men [10]. Especially hormonal milestones accompanied by fluctuations in estrogen levels such as menarche, pregnancy and menopause seem to have vast effects on migraine prevalence and frequency (Fig. 1). The onset of migraine in women usually coincides with menarche and a close relation between migraine occurrence and the menstrual
Nafamostat Mesylate remains during the reproductive years [11]. Approximately 50% of women with migraine are affected by MRM [12]; migraine without aura that occurs on day 1 ± 2 of the menstrual
cycle in at least 2 of 3 consecutive menstrual cycles with additional attacks with or without aura that can occur at other times of the month [4]. During perimenopause changes in migraine prevalence have been reported [13]. Major fluctuations in estrogen levels take place during perimenopause, ultimately leading to dropping levels [14]. The prevalence of migraine headaches during this period seems to be higher in patients who previously had a history of MRM and premenstrual syndrome [15] and [16].
