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Genetic requirement for Notch signalling to initiate NFIA MC1568 in the spinal cord. In PS-1?/? embryos Hes1 expression was strongly down-regulated (A and B) while Hes5 expression was unaffected (C and D). NFIA expression was almost abolished (E and F) while Glast expression was strongly reduced except in a small region in the vSC (G and H). Fgfr3 expression at e13.5 was almost abolished while OLIG2 was expressed in a somewhat enlarged pMN domain.
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Supplementary Fig. 9.
Genetic model interlinking different genetic pathways upstream and downstream of SOX1 during gliogenesis. The core components of this model can be summarised as follows: (1) Notch signalling induces a pro-astrocytic program of glial specification in the pMN by inducing the expression of NFIA in the VZ, in PAX6/SOX1/HES1/HES5-independent manner. (2) PAX6 and Notch signalling positively regulate independent mechanisms that affect SOX1/HES1 expression that inhibit MASH1 expression and thus MASH1-dependent OLP specification. Green arrows indicate induction; red arrows indicate repression of expression or of a mechanism. OL, Oligodendrocytes; AS, Astrocytes.