CD4+ T cell development is tightly regulated by many steps, including lineage commitment, progression and cell survival. CD8+ T cell development in LEC rats is unaffected, which suggests that PTPRK is involved in the lineage progression of CD4+ T Atazanavir rather than lineage choice between CD4/CD8 T cells. ERK1/2 is also involved in the lineage progression of CD4+ T cells but not the CD4/CD8 lineage choice. Therefore, PTPRK/ERK might control the lineage progression of CD4+ T cells, although ERK1/2 also has some role in CD8+ T cell development.
The present studies demonstrate neurotoxin PTPRK controls ERK1/2-mediated signaling. This novel interaction of PTPRK and ERK1/2 might provide new insight into not only CD4+ T cell development but also other ERK1/2-mediated cellular responses.
Acknowledgments
We thank Mrs. Kinouchi and Yamakawa for technical and editorial assistance. This work was supported by a Grant-in-Aid for Young Scientists (S) from the Japan Society for the Promotion of Science, Takeda Science Foundation, Uehara Memorial Foundation and Mochida Memorial Foundation.
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