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Philosopher's Stone, Complete - The item hunted down by every Alchemist, as it amplifies its wielder's alchemic power infinitely. It also can bypass the laws of equivalent trade. When the Elric Brothers were at the 5th Laboratory, they learn that the Philosopher's Stone is a byproduct of transmuting a certain number of human souls into a single stone. The legend of it bypassing equivalent trade was false as each time a human transmutation is done with it, a certain number of souls are taken away, eroding the stone. It also can transfer souls between bodies, though the soul also erodes. Hohenheim of Light created a Philosopher's Stone when his body began to degenerate and Dante used it to transfer his soul to another person. Hohenheim gave a piece to Dante who used it for the next 400 years until she ran out and had to set up the event that would create a new Philosopher's Stone.

Philosopher's Stone, Incomplete - It is incomplete and not as powerful as the real Philosopher's Stone, which is sometimes referred as the Blood Stone. However, it is still quite powerful, as many characters who possess this stone demonstrate, even though it sometimes has undesirable side effects. The Military first learn of its existence when such a stone was created and engineered by Tim Marcoh, though he regretted this achievement when his project was used in the Ishbal War.

Red Water - A liquid with the potential for alchemical amplification. It can be refined into an incomplete Philosopher's Stone either by a long and labor-intensive process, or by using the body of a pregnant woman as a living refinery. This substance is toxic to humans, but can be absorbed by plants. The question of whether the Red Water is composed of human souls like the complete Philosopher's Stone is not answered in the series.