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It all really depends on what your vision of the future is.

An stereotypical Utopia is usually indicated by bright, even lights and smooth edges. We don't see much dirt, or exposed machinery, and the whole world can look a little sterile, and lifeless. Colour contrast is very minimal. Typically these settings have some form of clean and reliable energy, pollution is nonexistent. We also don't see many crowds or over-population. The general idea is that society is good, and that any criminal elements are either insane, or simply power hungry. It's easy to flip these elements around, and create an Orwellian Police state. Where the government is in complete control of the populace. forced sterilization, behavior altering drugs, and constant surveillance are common place in such settings. Clothing wise, everyone usually dresses conservatively, variation between fashion styles are minimal.

In a more Cyberpunk dystopia, we see darkness and decay beneath a sea of neon. Overpopulation runs rampant, and the planet is quickly being depleted of natural resources. Cities have grown, becoming huge, almost cancerous entities, swallowing up the last few remnants of nature. In more futuristic settings, the entire planet could lay buried underneath the urban sprawl. There is a sharp division between the social classes. The rich live in towers, above the smog. The poor live in dark, rotting buildings, the more cramped and claustrophobic, the better. Crime and desperation go hand in hand. There are no super villains robbing banks, there are only people desperately trying to claw their way out of the gutter. Typical Cyberpunk fashion is dark and subdued colours for men. For women? the more outlandish the better.

Those are just the two extremes, of course. There's plenty of space in between. You'll have to ask yourself what role technology plays in your society, and how serious your going to be taking the science. Is FTL travel a possibility, or is deep space exploration conducted by robotic probes? Where do the Fantasy elements come into play? How far into the future are we talking here? Is Earth a distant memory, or are we still stuck in our own gravity well?

Don't worry so much about blurring the lines between Science Fiction and Fantasy. Star Wars wouldn't have been Star Wars without the force, nor would Dune have been so special without the all it's psionics. Every culture on Earth had some form of mysticism, so you'll have plenty to draw inspiration from, if you need it.

That is true. Since no one really knows what the future will look like, it leaves many possiblilites open.

Since comics are visual, you've also got to take into account how you want to introduce and explain the various aspects of the world. What sets sci-fi apart from everything else that includes technology and alternate-reality futures is the science part of the science fiction. If you're a creative person and can come up with some amazing sci-fi premises and awesome technology, good for you. Now how are you going to present the information to the readers?

You could go the "Hard Sci-Fi" route and have lengthy, detailed explanations of the world, how it came to be like that, and how the technology advanced to that level before you even introduce the characters, let alone the plotline.

On the other hand, you've got the "Soft Sci-Fi" option, where you introduce the important stuff as it comes up using characters and plot points to elaborate on certain points that you think the reader needs to know.

The more you know!

Also sometimes, in a sci fi, you could just have... one minor thing going.
Like a world where advanced bionic prosthetics are perfectly common.

If you want to read her comic, you can find it here.

I'd say her style worked out pretty well.