I highly recommended Diana L. Paxson's "Taking Up the Runes", as it is an excellent resource if one is seriously interested in learning the Runes.
It should be noted that the Runes are very tied to the Norse Gods/Goddess and the Norse culture in general. If you are seriously considering working with the Runes, it is suggested that you have a good relationship with the Norse pantheon. It is very hard to work with the Runes outside of their original context. They do not always have specific meanings, and much of the interpretation relies on having studied the Rune poems and knowing the culture and the nature of the God/ess associated with the Runes.
The following links might be useful as well...
The Poetic Edda (Elder Edda)
The Prose Edda (Younger Edda)
Sagas (and other links of interest)
Links to Several Versions of the Rune PeomsStay far away from anything written by Ralph Blum, and DJ Conway.