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I don't know what 40mgs of Prozac would do to you but messing around with your medications, especially if they are ones that regulate brain chemicals are never a good idea.

If you really are worried that your medication isn't doing anything for you you should take it up with your doctor, not just experiment on your own.

Supposedly, you can quit a low dosage of prozac (but not other meds) cold turkey. I was advised to do so before, I did, and nothing bad happened to me (no side effects or anything). However, it is important to discuss switches in your meds with your doctor, because they can give you the best advice. Playing around with your own meds is a bad idea.

Quitting ANY kind of medication for ANY mental disorder is always a BAD IDEA if you do it COLD TURKEY.

My sister's doctor told her to quit Prozac cold turkey last November. She was on a low dosage. For a few weeks she was fine... then she became suicidal, started cutting herself (she wasn't that way before), and was seeing and hearing things that weren't there. Not to scare you, but she kept hearing people telling her to do things and seeing people covered in blood randomly. Apparently, and surprisingly, this is actually not uncommon with antidepressant withdrawal!

Having been on lots of different medications at one time or another (Zoloft, Paxil, Prozac, Lexapro, Celexa, Wellbutrin, Trazadone, Effexor, etc...), I can say from personal experience that while you may feel great the first few days you don't take it, eventually you more than likely WILL feel like s**t and get massive withdrawal symptoms. With my experience of talking to others that have tapered off antidepressants, it really doesn't matter how much or how little you were prescribed to take. I've known some people that had to cut their pills down to half for a week, then 1/4, then 1/8, until they were barely taking more than a pinch of powder, and even THEN when stopping they still got the side effects!

As for my personal experience with withdrawal, I had terrible withdrawal symptoms from each of the medications described above for about a week. The worst was Paxil and Effexor. Effexor I actually became so sick that I couldn't work for about seven months, because my body literally went to hell. It was like having a constant flu that whole time, and the seeing and hearing things crap that so many people experience. I'm an otherwise pretty sane, level person... but when you start seeing blood dripping down walls randomly, or wake up and hallucinate and see someone standing over your bed with a knife... you kind of have to wonder.

Because I have so many of the side effects from all these medications I've been on (while on them), my doctor has actually told me to only take my Lexapro every three days, and instead of taking 30mg, take 40mg. Lexapro is however, quite honestly probably the safest antidepressant out there, along with Wellbutrin, so I don't know what sort of effect doing the same with Prozac would do to you. Prozac is an older drug, however, so I'd be willing to bet you'd get more side effects than if you were doing this with one of the drugs I just mentioned. I would highly recommend against it unless speaking with your doctor first. Most people, when doing that with their antidepressant, get a crazed mood that I've found is very similar to taking speed. It's not fun and it makes you feel like trash.

On the other hand, I have some other questions for you. How long have you been on Prozac in the first place? It sounds that if you think this is a placebo, then perhaps you haven't been on the medication long enough for it to take effect... if that's the case, most antidepressants can take up to 4 months to build up in your system. If you don't take them -every day- during this time, then that only delays their effectiveness even further.

And, by the way, 40mg of Prozac is actually a lot. Most doctors only start patients out on 10mg of it. Like Rainbowsquirrel said, some med's dosages do more than others. And I can verify the stuff about serequil, my sister's on that and I'm always amazed of how hard she falls asleep at night. xd

I don't know a lot about depression medication, but I'm pretty sure that taking more than the recommended dosage is a really bad idea.

Even if you are weaning yourself off it it's not the best idea to do it without doctor assistance. They go to school for a long time and make a lot of money for a reason. They have knowledge that we just don't.