While the film will feature a "brand new storyline", promotional footage states that the film will be set "7 years from Raccoon City" two years after the destruction of the Umbrella Corporation seen in Resident Evil: The Umbrella Chronicles, and one year after the kidnapping of Ashley Graham (Resident Evil 4), placing it in the fourth quarter of 2005. The trailer implies that the film or part of it will take place in an airport terminal. Zombies are shown as overrunning the terminal and killing SWAT officers. The teaser included with the Resident Evil: Extinction DVD and Blu-ray Disc releases confirmed the appearance of Leon S. Kennedy and Claire Redfield.
Resident Evil: Degeneration Teaser
[Claire]

[Leon]