Whatever direction this mess will take eventually, I for one just hope that Sanji will get some pretty sweet justice on his jerkbutt of a family. And get back to being the awesome Strawhat pirate he is.
Also... I hope that once this saga is over and done with, the next big one involves Zoro at the center of it and we learn more about his past. I get the feeling the more we get closer to the end of the story, major arcs will focus on the rest of Luffy's crew and learn about their family history, last names (for those who have none), and other unknown details that'd be cool to find out. In the end, I see Luffy learning more about his family in preparation for finding the One Piece.
Personal wish: Luffy find out that he's related to both Ace and Sabo, as well as Roger (it's my belief that Roger is the brother of Luffy's mother, and that's how he got Garp to take care of Ace; as for how Sabo can be related, I have this crazy idea that his parents are somehow connected to either the Monkey or Gol families). Would be pretty darn interesting to find out if any of these ideas become canon in some form or another.