In recent times, high
GSK1059615 (magnetic sector) ICP-MS has become the preferred atomic spectrometric method of detection, providing sensitive and time efficient iron determinations whilst excluding isobaric interferences. Isotope dilution is often used for quantification, either with co-precipitation or on-line solid phase preconcentration. An attraction of isotope dilution is that it is an absolute and hence traceable method that does not require external standards or standard additions. Hence matrix interferences and variations in recovery are not a significant problem. Magnesium hydroxide co-precipitation (Wu, 2007 and Wu and Boyle, 199
cool requires minimal use of reagents and hence gives a very low reagent blank, with reported detection limits of 50 pM (Wu and Boyle, 199
cool and 2 pM (Wu, 2007). On-line solid phase chelation has reported detection limits of 15 pM with 8-hydroxyquinoline (8-HQ) immobilised on silica gel (Akatsuka et al., 1992), 21 pM with Toyopearl AF-Chelate-650M (iminodiacetic
acid chelating group) (Milne et al., 2010), 70 pM with nitrilotriacetic acid (NTA) Superflow™ resin (Lee et al., 2011) and 14 pM with a “seaFAST” column (co-immobilised ethylenediaminetriacetic acid and iminodiacetic acid chelating groups immobilised on a hydrophilic methacrylate polymer) (Lagerstrom et al., 2013).
