Fig. 4.
EUCM BI2536 differentiate into osteocyte, chondrocyte, adipocyte, and neuronal-like cells. The panels display representative photomicrographs of: (A) osteoblasts detected by Alizarin Red staining (magnification 30×); (B) chondrocytes detected by toluidine blue staining (magnification 15×); (C) adipocytes detected by Oil Red O staining (magnification 30×); (D) brightfield photomicrograph of neuron-like cells derived from EUCM with multiple axon- and dendrite-like processes typical of primary neurons in culture (magnification 20×).
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Neuronal differentiation of EUCM cells
EUCM cells were treated to become neural stem cells and neuronal cells as described previously [22] and [23]. After treatment, the EUCM cells adopted a morphology typical of neurons with axon- and dendrite-like processes and the appearance of primitive networks of processes typical of those observed in primary neurons in culture (Fig. 4D). This observation parallels that made for porcine and human UCM cells [23], in which UCM cells were found to differentiate into neural cells with a similar morphologic appearance as shown in Fig. 4D.
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