Figure optionsDownload full-size imageDownload as PowerPoint slide
Knockdown of CK2α+β elicits ectopic mc’s on the scutellum and wing ON-01910 akin to h mutants
While RNAi against CK2α or CK2β elicited ectopic MC’s, these flies did not exhibit ectopic mc’s as in h1/h1 animals (compare Fig. 3B, F, and G). We thus tested whether RNAi against CK2α+β would elicit ectopic mc’s on the scutellum and the L2 vein, and mimic h1/h1 ( Fig. 4 and Fig. 2), but not h2/h2, h2/Tm3 or h1/Tm3 flies ( Fig. 4B and inset). Similar to h1/h1 flies, RNAi against CK2α+β elicited ectopic mc’s on the scutellum and wing veins ( Fig. 4C–E). Moreover, these flies displayed mc’s along the L2 and L5 veins, both also affected in h41/Tik trans-heterozygous flies ( Fig. 2 and Fig. 4F). Thus, knockdown of CK2α+β elicits ectopic mc’s on the scutellum and along the L2 and L5 wing veins, phenotypes that closely mimic mutations in h. Together, these results provide strong evidence that attenuated levels of CK2 elicits phenotypes that mimic h loss of function in vivo.
Manage Your Items
- Avatardress up & check your inventory
- Avatar Builderbuild your dream avatar
- Aquariumcreate the perfect fish tank
- Carcustomize your ride for rally
- Housedecorate your gaia house
- Personas (beta)build your Persona
- Sign Up for Gaia News Weeklyproduced by Gaia art community for all Gaia users
Other Stuff
- Mailcheck your private messages
- Friendsconnect with your friends
- Profileedit your profile page
- Journalsyour personal journal/blog
- Achievementssee what you've accomplished
- Account Settingsadjust your preferences
- Gaia Labssee what we're cookin'
- Favoritessee your collections
- Marriageget Married!
- Vlogsee our vlog and Gaians latest creations!