Hueco Mundo is located between the human world and Soul Society, though it is separate from the bordering dimension known as dangai. It can only be accessed by tearing the dimensional fabric separating the worlds, which allows Hollows to travel to any other dimension at will. Depending on the Hollow, the effect of this process varies. he landscape of Hueco Mundo is a seemingly never-ending white desert, with dunes like those of the Sahara. The desert is littered with what appear to be boulders and shriveled trees, but these are actually a form of quartz. In Hueco Mundo, the moon is on the opposite lunar phase of that in the human world. Like in Soul Society, the atmosphere is filled with Reiryoku in the form of Reishi, but it is more concentrated, thus allowing smaller Hollows to gain nourishment despite the lack of human souls.

Like that in real world deserts, active life in Hueco Mundo appears to be few and far between. Hollows generally seem to dwell below the surface or in other areas until something provokes them to leave their shelter, like the intrusion of a foreign entity. According to the Shinigami, all Hollows dwell in Hueco Mundo regardless of their shape, size, or power. In the anime, Hollows can also drag other spirits into Hueco Mundo