It takes place in a hospital/clinic and the main character is Dr.House, he has three doctors who work with him. Plus a few others, one is houses friend who is a cancer specialist and one of the hospital heads, for a while there was this buisness man who had it in for House, but I won't go into that.
House is brilliant jackass. He is very intelligent and often saves the day, but he's rude, nosy, and a pain in the a**. He prescribes medicine without knowing excatly what a patient has. He and his team work on rare illnesses(sp?) and problems.
(I'm doing a realy bad job of discribing the show, partly because I can never remember all thier names and partly because I'm no good at describing things.)