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I started crying when Denny died (of course), but also when Christina goes up to Burke and gives him a hug and says, "Don't ever die," then bursts into tears. crying

Yes I have cried alot during Grey's Anatomy. Not because of the main characters' stories but some of their patients' situations make me cry. Like when someone loses a baby or a child... with the characters... Denny dying was very sad and Burke/Christina in last week's episode when he closes the door on her... I didn't cry but that was sad.

Hmm (besides ALL of the ones mentioned so far)
The one where Izzy has found out that Alex was sleeping with the nurse, and none of her friends are there for her. She says something like "I never once said you would be better without McDreamy..." and she's JUST SO SAD! Stupid bad friends...

i was bawling my eyes out during the bomb episode and i cried when denny died becuase alex grabbed izzie and was hugging her....so sad

Once again, the episode where denny dies. But not denny dying... the saddest part is at the end when Alex scoops izzie up and cradles her and you can tell that even though he knows he messed up big time, he loves her some big huge impossible amount in a way noone can ever understand.

Every scene where people die makes us sad or cry.

But the most touching moment for me was on the episode themed "crossing the line". Meredith cried hard because she realized that she does not want her mother to be alone or die alone.

Remember the train wreck episode? God, that was so sad. The two people that got stuck together had to choose which of them would live.

Another one I cried at was a recent episode where a pregnant lady and her husband came to the hospital because the lady fell in the shower and landed on her stomach, so they came to see if everything was okay. Then Addison talk an ultrasound and found out the baby had died, so she told the parents and they cried and everything. But the part that got me was when Addison told them that she had to remove the dead baby and it was just so sad.

I manage to cry about something in every episode, I guess I just cry a lot. So I try not to watch it in mixed company, I don't want to hear the teasing I get because "it's just a show". Some of the issues in the episodes are just too close to home.

George making the decision to pull the plug on his dad was one of the saddest moments, and I definitely cried through that one. There were lots of other sad moments, but for George who knew what was happening was torn between the practical Dr side and the emotional family side.