In this alternate-reality fantasy world, there exist normal human beings...as well as others that possess animal-like characteristics. These mysterious beings (called +Anima) are shunned by "normal" society. The story focuses on four of these special beings: Cooro (a crow), Husky (a fish), Senri (a bear) and Nana (a bat). These four friends travel to not only find others like themselves, but to also gain acceptance in world cruel to anyone or anything that is different