I don't know how that would really come up at any party unless it may somehow come up at the LA Convention over the summer with the anime thing. There's a bunch of hotel parties, but I doubt anyone would be talking about them besides those specific tourists.
It really depends if you're into it.
Anyone has the potential to nerd out.
Sometimes if I'm a fan of the anime, I'll nerd out.
But if I don't know anything about it, I'm all "WTF are they talking about?"
Once on this party vote 2 of my friends played yugioh the whole time, of course they got the gay comments. But one of my friends who was playing was a football player. As soon as he stood up, everyone backed off. xD idk why this reminded me of it.