Cuddles is a yellow rabbit with pinkish cheeks who inexplicably wears pink bunny slippers. He is one of the four primary characters in the series along with Giggles, Lumpy, and Toothy.

Both his white fluffy curly hair tuft and cotton tail look exactly the same. His long ears move to match how he feels; for example, if he is happy, they stay up, and when his feelings are hurt, they drop. He is beta-carotene intolerant and appears to be epileptic. It is also shown he has a collection of antique electric toothbrushes. His fur is SPF 90 to minimize exposure to the sun.

Cuddles' personality is somewhat mixed. On one hand, he is dangerously mischievous and self-centered, which often leads to both his death and other characters' deaths. On the other hand, he is mostly friendly and caring, making his personality more complex than the others. He was seen to have multiple houses, but his official one is known to be a Hollow Tree, as it is the only one to appear more than once.

He is particularly good friends with Toothy, Flaky, and Lumpy. Cuddles and Giggles are also very close, and it has been hinted several times they have crushes on each other. Their love relationship is most prominent in the Fall Out Boy music video "The Carpal Tunnel of Love", which featured Happy Tree Friends characters and the episode "I Nub You".

A Cuddles icon appeared in an episode of another Mondo Flash internet cartoon The God & Devil Show on God's keys.

Apparently, Cuddles' deaths involves his body getting sliced up, making him a rather unfortunate character in the series.