Marvel Universe (Earth-616)
Wade W. Wilson
Jack, Merc with a Mouth, Merc, Wade T. Wilson; formerly Chiyonosake ("the Wolf of the Rice Wine" wink , Chatterbox, Rhodes, Corpus, Lopez, Hobgoblin, Tom Cruise, Peter Parker, many others
Secret, known to certain government officials
Mercenary; former enforcer, government operative, sumo wrestler, soldier, assassin, others
Place of Birth
Thomas Wilson (father; deceased), Hailey Wilson (mother; deceased), Gretchen Wilson (ex-wife)
Code Red, Deadpool Corps Agency X, formerly operative of S.H.I.E.L.D.; Six Pack, One World Church, DP Inc., Weapon X, Heroes for Hire, Secret Defenders, Frightful Four, Team Deadpool, Landau, Luckman & Lake, Department K, U.S. Army; former employee of Tolliver, Kingpin, Taskmaster, presumably others, Great Lakes Initiative reserve member. Wrongly claims membership in the X-Men
(Originally) Blond; (currently) Bald
Regenerative Healing Factor: Deadpool possesses a superhuman healing factor derived from that of the mutant Wolverine that allows him to regenerate damaged or destroyed bodily tissue with far greater speed and efficiency than an ordinary human. Deadpool is able to heal injuries such as slashes, puncture wounds, bullet wounds, and severe burns within moments. His healing factor is developed to the point that he can regrow missing limbs and organs. As Deadpool had cancer at the time of the gene therapy which endowed him with these abilities, it bound to the "healing factor" so that in a sense the cancer is his healing factor, which is why his skin is still horribly scarred. Unlike Wolverine’s natural healing factor, Deadpool’s is mentally driven to a partial extent.
* Foreign Chemical Resistance: Deadpool's body is highly resistant to most drugs and toxins. For example, it is extremely difficult, though not impossible, for him to become intoxicated (Blind Al made several references to Deadpool being hungover since he once drunkenly spoke to the Telletubbies on the TV he was watching). He can, however, be affected by certain drugs, such as tranquilizers, if he is exposed to a massive enough dosage.
* Disease Immunity: The unique regenerative qualities of Deadpool's healing factor also extends to his Immune System, rendering him immune to the effects of all known diseases and infections.
* Extended Longevity: Deadpool's healing factor provides him with an extended lifespan by slowing the effects of the aging process to an unknown degree. His life span is extended to such a degree, that he is even alive and still in business as Deadpool even 800 years from the present as shown when the new X-Force encountered him in the future recently.
* Telepathic Immunity: The healing factor causes his brain cells to be in a constant state of flux and regeneration, rendering him immune to psychics such as Professor X and Emma Frost.
* Peak human Strength: Deadpool possesses great, though not unnatural, physical strength. However, he does have at least the strength of an Olympic level weightlifter. He is capable of lifting at least 420 lbs but no more than 800 lbs.
* Superhuman Stamina: Deadpool's musculature generates considerably less fatigue toxins than the muscles of an ordinary human being, granting him superhuman levels of stamina in all physical activities. He can physically exert himself at peak capacity for several days fatigue begins to impair him.
* Superhuman Agility: Deadpool's agility, balance, and bodily coordination are enhanced to levels that are beyond the natural physical limits of even the finest human athlete.
* Superhuman Reflexes: His reflexes are similarly enhanced, superior to those of even the finest human athlete.
* Immortality: Deadpool has actually met and established a relationship with the personification of Death in the Marvel universe and as a result has been cursed by T-Ray, at the behest of Thanos, to be unable to die..
Deadpool is an extraordinary hand-to-hand combatant and is a master in multiple unarmed martial arts. He has been shown fighting such amazingly skilled fighters as Wolverine and Taskmaster and even defeating them in hand to hand combat. This shows that Deadpool himself is among the most skilled fighters in the Marvel universe. He is a master of assassination techniques, is a master marksman, and is highly skilled with bladed weapons (frequently carrying two swords strapped to his back), and a number of other weapons. He is fluent in Japanese, German, Spanish, amongst other languages..
Deadpool employs any number of weapons depending on his current assignment. Most often, Deadpool uses guns, grenades, sais, knives, and katanas. Wade can use any weapon known to man and learn how to use the weapon in less than 5 minutes. Wade is mainly seen using a gun.
Deadpool utilizes a teleportation device located in his belt to whisk him out of (and occasionally into) danger, as well as a holographic image inducer that he can use to disguise his true appearance as necessary.
Teleportation Device. Deadpool is currently able to 'bodyslide' to where ever Cable is present, through Providence.
New Mutants #98
After his mother died from cancer, his father killed by a drunken friend, and he was kicked out of the United States Army Special Forces, Wade joined Project X. 
Little was known of Wilson's subsequent mercenary activities. At one point he was active in Tangier, Morocco, where he romanced a woman named Francie. When this relationship soured, he traveled throughout Asia, and was hired in Japan by a crimelord, the Boss, to infiltrate a sumo-wrestling ring owned by a rival criminal, the Oyakata. Wilson spent three years as a wrestler under the Oyakata's tutelage and became romantically involved with his mentor’s daughter, Sazae. When the Boss finally ordered the Oyakata's murder, Wilson refused to complete his assignment, allegedly the first time he had ever done so, and relocated to the United States.
In America, Wilson met and fell in love with teenage prostitute Vanessa Carlysle (Copycat), with whom he shared dreams of a better life. Wilson was subsequently hired by Middle Eastern interests to assassinate a blind British government operative named Althea, also known as Blind Al, but upon arrival at the Zaire base where she was stationed, he killed everyone except for Al who had fled. Wilson’s employers sought vengeance for his failure by targeting Vanessa, who was rescued by Zoe Culloden, an employee of the interdimensional firm Landau, Luckman, Lake, and LeQuare. Culloden was keeping Wilson under surveillance, believing he was destined to play a vital part in a potential threat to the world. Learning that he had contracted cancer, Wilson broke up with his girlfriend Vanessa rather than force her to remain with a terminally ill man. He even gave up his chemo treatments, not wishing to prolong things.
In Canada, he was offered hope in the form of Department K, a special weapons development branch of the Canadian government. Wilson became a test subject in Department K’s branch of the joint U.S./Canadian superhuman enhancement project, the Weapon X Program; his cancer was temporarily arrested via the implantation of a healing factor derived from another Department K agent, the mutant adventurer Wolverine. Wilson was active in a covert field unit alongside the near-invulnerable Sluggo and the cyborgs Kane and Slayback. Vanessa herself was later affiliated with the team after having manifested mutant shapeshifting abilities, calling herself Copycat.
During one mission, Wilson killed his teammate Slayback. As a result, he was rejected from the Weapon X Program and sent to the Hospice, allegedly a government facility where failed superhuman operatives were treated. However, unknown to the Canadian government, the Hospice’s patients served as experimental subjects for Doctor Killebrew and his sadistic assistant Ajax (known then as The Attendant), with the patients placing bets in a "deadpool" as to how long each subject would live. Killebrew subjected Wilson to various torturous experiments for his own deranged satisfaction. In due course, Wilson formed a romantic relationship with the cosmic entity Death, who regarded him as a kindred spirit. Wilson started trying to kill himself, to join Death - going so far as to start taunting Ajax by saying his real name (Francis) over and over, which earned him the respect of his fellow Hospice patients. Then Ajax, angered by Wilson’s taunts, lobotomized Worm, the closest thing Wilson had to a friend. At Death’s prompting, Wilson killed him to end his suffering. However, under Killebrew's rules any patient who killed another was to be executed; Ajax subsequently tore out Wilson’s heart and left him for dead, but Wilson’s thirst for vengeance was so strong that it jump started his healing factor, regenerating his heart, although not curing his scarred body. Wilson then escaped the now-empty room and attacked the guards, making his way to Ajax. Wilson shot him in the chest with two automatic rifles, leaving him for dead. Taking the name Deadpool, escaped from the Hospice with his fellow patients.
Deadpool and Copycat in Deadpool - The Circle Chase #04
Following his escape, Deadpool served for a time as an enforcer alongside the surgically altered criminal Hammerhead. He soon returned to his freelance mercenary activities, donning a costume in keeping with his new identity. At some point during his mercenary career he was employed as an assassin by Wilson Fisk, the Kingpin of crime. He also clashed with Wolverine, at that time a spy for the Canadian government. Also, at some point during these years, Deadpool caught up with Blind Al and kept her a prisoner in his home. Al’s attempts to escape only resulted in death for those whose help she sought, leaving her no choice but to resign herself to captivity.
Some years after escaping the Hospice, Deadpool, perhaps seeking compensation for the injuries inflicted upon him by Killebrew, returned to the Canadian government and was treated by Doctor Walter Langkowski, the bestial Sasquatch of Canada’s super-team Alpha Flight. He also acquired a teleporter around this time. Deadpool soon found government work unsuited to his temperament, and he abandoned this endeavor. Hired by the criminal genius known as the Wizard, Deadpool at first went to the wrong address and received a job impersonating the criminal Hobgoblin. When again contacted by the Wizard, he joined with fellow criminals the Taskmaster and the Constrictor (Frank Schlichting) in a short-lived version of the Frightful Four. When this plan also failed, Deadpool sought to reclaim his position as the Kingpin’s assassin, only to be challenged by fellow assassin Bullseye. Deadpool began frequenting the mercenary hangout called the Hellhouse, where the diminutive Patch issued assignments. There he clashed with T-Ray, a voodoo-sorcerer and assassin to whom he took an immediate dislike. He subsequently found employment with the time-traveling arms merchant Tolliver, in whose service he was reunited with Sluggo and Copycat. Unbeknownst to Deadpool, Tolliver subsequently sent Copycat to impersonate another mutant mercenary, Domino. Deadpool also recruited a man named Weasel to act as his weapon supplier, and the two became fast fast friends, despite numerous acts of violence against him.
After some time in Tolliver’s service, Deadpool was sent to kill Cable, the mutant soldier from the future who was in fact Tolliver’s father and in whose company Copycat was impersonating Domino. However, Deadpool met defeat at the hands of Cable and his new charges, the young mutants in training known as the New Mutants. When Cable reorganized the New Mutants as X-Force, Tolliver was seemingly slain in battle with them, setting off a search by his various mercenaries for the advanced technology he had left behind. Deadpool’s participation in the search was interrupted by the surprising interference of Slayback, who had cybernetically reconstituted himself after being slain by Deadpool and was eager for revenge. In the course of the ensuing battle, Copycat was gravely injured, and Deadpool sacrificed part of his healing ability to save her life.
Deadpool subsequently helped X-Force member Siryn against the unstoppable Juggernaut and her uncle, Black Tom Cassidy, who had forced Killebrew into their service. Deadpool developed a strong attachment to Siryn, who only partially returned his feelings.
The Genesis Coalition later hired Deadpool to capture Silver Sable - a mission that also threw him into battle against Daredevil, whom was then no longer going by his real identity. He took the fight to the sewers where he was 'convinced' to hand over the information of his mission, for triple his commission. He was also put on retainer, in case he thought about choosing to take a mission against Sable's interests again.
Unsure of his worthiness, Deadpool sought out Copycat, only to find she was now dating Kane. Deadpool fought both Kane and Wolverine, who had been sent to check on Kane by a mutual friend. Deadpool was subsequently abducted by information brokers seeking a cure for the Legacy Virus but was rescued by Wolverine and the mutant mercenary Maverick.
Soon afterward, Deadpool was approached by Zoe Culloden of the rechristened Landau, Luckman and Lake who believed he was destined to be the Mithras, one who would help usher in a golden age for Earth. Skeptical, Deadpool turned her away, only to be hit with a string of personal failures. These included the alienation of Weasel and Blind Al (whom had been meeting, against Deadpool’s instructions), a defeat at the hands of T-Ray and loss of good grace at Hellhouse.
He also met up with Bullseye to do a pro-bono job in Greece, where the assassin told him that he was losing his edge - as shown by the fact he only wounded the people he was supposed to be killing. Deadpool disputed the fact, even going as far as to accuse the now-dead guards of moving the castle he was supposed to blow up with a sheep-rocket, when he hit the tower instead. Bullseye told Deadpool that he wouldn’t kill him for one reason - he made him laugh. It was revealed that they had worked together before, in the army - where Bullseye nearly lost his pinky toe because they were laughing so much on a mission.
Hoping to turn over a new leaf, he found that killing was not so easily left behind when, at the behest of the ghosts of his fellow former Weapon X inmates, he killed Ajax. The former Attendant had been tracing down and killing them all, one by one, mainly wanting to kill Deadpool. This was possible partly due to the help of Dr Killbrew, who lost his life to Ajax. Before he was remotely-kidnapped by his teleportation belt and Ajax, he told Blind Al that she was now free.
After being employed by L, L & Lake, he was hired to be part of a Heroes For Hire mission. Much to the annoyance of Colleen, Misty Knight, Luke Cage and Iron Fist. When he found that he would have to climb a mountain to their castle destination - and that HFH lacked a flier - he decided to teleport up instead. He was at a loss for words when he was seen as soon as he appeared at the top. The essence of surprise lost, the HFH attacked, finding an iteration of Wild Pack waiting for them. After the rest of Heroes For Hire were defeated, Deadpool decided to teleport to safety. A while later, Deadpool located and freed Misty and Colleen from the room they were being held in by Madcap, including bringing their weapons to them. When asked where he concealed them, he replied with "Do you reeeeally want to know? It involves an awful lot of lubricant.". Deadpool and the girls met up with Luke Cage who, when they located their mark, turned out to be working to an alternate agenda. Claiming he could smell a traitor when he saw one, Deadpool opened fire. Cage managed to escape minutes later.
Deadpool acknowledges his existence in a comic book.
Deadpool hoped to move forward by accepting Culloden’s offer, only to be dismayed when he learned that his destined role was to kill Tiamat, a potential threat to the arriving “Messiah.” Deadpool instead killed the Messiah when he learned that it brought not true peace but mindless bliss instead.
Continued Mercenary Life
Having lost his optimism about bettering himself, Deadpool returned to his mercenary life. Troubled by recent events, he sought the counsel of deranged psychiatrist Doctor Bong, who advised him to work out his difficulties in a fight with Wolverine. The fight indeed cleared Deadpool’s mind, but his psyche was dealt a stunning blow by the resurrection of Mercedes Wilson whom Deadpool still believed to be his wife. T-Ray revealed himself not only as the one responsible for her resurrection, but also as the true Wade Wilson. The revelation did not break Deadpool’s spirit as T-Ray had hoped, for the mercenary still harbored hopes of bettering himself. Swearing vengeance, T-Ray departed with Mercedes Wilson.
Later, in the course of an assassination assignment against author Duncan Vess, Deadpool again clashed with Wolverine who had sensed something strange about Vess. The pair found themselves battling Vess’ vengeful kinsmen after the author was revealed to be a werewolf, and they parted on good terms. Weeks later, Deadpool sought medical treatment for Siryn, who had been injured in a mission with X-Force. Allying himself with the mysterious Watchtower group, Deadpool captured Wolverine in exchange for Siryn’s treatment. Siryn was cured, while Wolverine easily outfought his captors.
Seeking a new place for himself, Deadpool briefly shared an apartment with fellow mercenaries Titania and the Constrictor. However, Titania proved to be Copycat in disguise, and the apartment was destroyed by the The Wizard and the Taskmaster, both seeking revenge on Deadpool. He next established a secret warehouse headquarters and took on a young sidekick who called himself Kid Deadpool, but the youth, also seeking vengeance for Deadpool’s part in his father’s death, blew up the warehouse.
Deadpool, unlike most characters, is aware that he is in a comic book and able to express his thoughts via captions.
Deadpool was then tracked down by the feral mutant Sabretooth and invited to join the new Weapon X Program. Impressed by Weapon X’s upgrade of his healing factor, he agreed to join, but soon found the organization’s methods to be too bloody even for him. After the death of Copycat at the hands of Sabretooth, he confronted the Director, only to have his healing factor reversed to the point where he again lost physical cohesion and died. The lingering effects of Deadpool’s healing factor upgrade resurrected him, leaving him amnesiac. A chance encounter with Weasel restored his memory, and he discovered that four other individuals had laid claim to the Deadpool name. These impostors were aspects of his own personality given form by a device called the Gemini Star, wielded by his nemesis T-Ray who had been hired by the intergalactic villain Thanos, himself enamored of Death and jealous of Deadpool’s relationship with her. T-Ray intended to manifest and extinguish every aspect of Deadpool’s personality, leaving him an empty shell; however Deadpool damaged the Gemini Star, causing his personality fragments to be absorbed into T-Ray, rendering him comatose. With T-Ray out of the way, Deadpool claimed his identity as the true Wade Wilson after all.
Following an assignment against the Four Winds crime family, Deadpool gained great status as a mercenary and formed a company called DP, Inc., aided by business partner Sandi Brandenberg. His success was short-lived, however, when the Black Swan, a fellow assassin who had actually slain the Four Winds himself, sought vengeance for Deadpool’s wrongful claim. Both men were believed dead after an explosive confrontation, but the Swan’s telepathic power caused the memories and skills of both himself and Deadpool to merge in the corpse of his underling Nijo. Deadpool’s healing factor resurrected Nijo, whose mind was created from an amalgam of Deadpool and the Swan. Injured and amnesiac, found his way to Sandi’s apartment. Sandi believed Nijo to be Deadpool and nursed him back to health.
The man took the name Alex Hayden and together they started "Agency X", with Hayden dubbed Agent X after the company. Most believed that Hayden was Deadpool with a case of amnesia. In fact, the truth was more complicated, as discovered when the Black Swan showed up with a "tabula rasa" Deadpool in tow, who Hayden immediately shot in the head. Deadpool's own personality was slowly growing back, unwittingly accelerated by Hayden's bullet to his head.
In an attempt to regain the parts of his mind he had lost, as well as remove the pieces of their minds he wanted rid of ("You and Wilson have my skills, Mr Hayden. In return, I received a taste for Radiohead and an encyclopedic knowledge of pornographic knock-knock jokes. Yes, I'd like to switch back if possible" wink , including Nijo's sense of honor, Swan proposed a three-way mind meld. Hayden agreed. However the Swan, being an evil cad, attempted to double cross the other two and kill them as soon as the process was complete, but while he concentrated on Hayden, Deadpool immediately stabbed the Swan in the back. Deadpool, Hayden and Hayden's allies Outlaw and Taskmaster eventually defeated and killed the Swan and had him stuffed so that the healing factor couldn't resurrect him. Hayden later used the corpse as a surfboard. Shortly after, Deadpool became one of the villains sent to find the so-called Identity Disc possessed by AIM.
Partnership with Cable
Deadpool partnered with his former enemy, Cable. The two were involved with a terrorist plot aimed at unleashing the shape-shifting "Façade Virus" upon the world. After both were infected with the virus it was necessary to merge their DNA structure, so now Cable has some of Deadpool's DNA and vice versa. If they didn’t do that, Deadpool would have become a goo and Cable’s techno-organic arm would have taken him over completely. That meant that whenever Cable used his teleporter to "bodyslide", both he and Deadpool teleported together -- sometimes literally (a "bodyslide by one" resulted in them being badly integrated into a single body, forcing a messy separation, which, thanks to the DNA share with Wade, Cable was also able to recover from). As a result of the Façade in his system, Deadpool's skin was temporarily cured of the hideous tumor-scarring. Once Cable shut down all infections of the virus worldwide however, Deadpool was returned to his usual self.
Cable & Deadpool #2
The X-Men, including Cable's father Cyclops, then hired Deadpool to put together the pieces of a mini-teleporter that they could use to stop Cable, who had achieved the peak of his powers and was causing worldwide political ructions in attempting to unite the world's populace, without quite knowing what the device was.
After Cable then delivered a stark message to the world's leaders - deliberately setting them all against him by threatening to throw all their missiles into the sun - Deadpool and the X-Men mounted an attack on Providence, whereupon Deadpool promptly turned on the X-Men, shooting Wolverine and Bishop to prevent them attacking Cable. Cable then confessed to Deadpool that he'd wanted him to kill him, to show the governments that they could achieve something by working together. Cable was then attacked by the Silver Surfer and burnt out his powers in the ensuing battle. Deadpool saved his life by removing the telepathic and telekinetic parts of his brain with the mini-teleporter. He then set about recovering some non-viral techno-organic matter to replace the damage to Cable’s body, crossing swords with Agent X during seeking help from the Fixer. The aftermath of this, however, left Deadpool unemployable - whereupon Cable began to covertly hire him to run missions for him, without revealing that he was the one doing so.
Shortly afterward, Deadpool rescued Cable again, teleporting through several alternate worlds to retrieve him. Cable returned the favor by repairing Deadpool's brain damage before his powers burnt out once more, though his personality and powers remained unchanged.
After being hired to assist local resistance in Rumekistan against Flag Smasher, and fighting with Citizen V, Deadpool decided to try and get hired to be a SHIELD-licensed bounty hunter. His job would be to hunt down super-powered individuals to get them to register with SHIELD after the Superhuman Registration Act (HR421). He did this by trying to arrest the Great Lakes Champions, only to find they had registered that morning - after being trounced by Squirrel Girl. He was hired, then followed Cable to find where Captain America, whom was on the run from the Act, might be, finding him and the main-force of the Resistance in a warehouse. In the fight that followed, he was successful until Cable showed up. Cable bodyslid Deadpool to the White House, where he spoke to the President whilst Deadpool relieved himself. Upon his return, the President ordered Deadpool to capture Cable. This failed due to Cable’s technology.
Whilst trying to fix his somewhat shattered reputation, he kidnapped Taskmaster and forced him to try and win a fight - whilst his own hands and feet were tied. This was to convince four Government higher-ups (also kidnapped) to hire him, after the recent set-back against Cable. Once Deadpool had indeed won the fight, he was informed that they knew how good he is, but he is too immature. After hearing this, Deadpool was dusting Taskmaster off and thanking him for losing on purpose. Taskmaster revealed that he hadn't let Deadpool win, he was just that good that he could win with his hands and feet tied. Taskmaster was then beaten further by Deadpool.
Days after this, Deadpool awoke in what he thought was a very large hospital room. He had in fact been shrunk with Pym Particles, to a size where one piece of popcorn made an entire meal. Weasel later revealed that he had obtained the Pym particles and set up Deadpool so that he would take on the Rhino. Which he did. Rhino burst into the room where Deadpool was and proceeded to make him into a key-chain and take him to the Three Strikes Bar, filled with Z-list badguys. After several humiliating events, including being flushed in a toilet, Deadpool managed to beat up each and every one of them, including Rhino - whilst still only a few inches high.
Deadpool was approached by Agency X to find and rescue Agent X, who had been captured by Hydra. His payment being "Four reasons" on the chests of Sandi and Outlaw. Deadpool and Weasel went to Afghanistan and located the Hydra base, which Deadpool (being less than a foot tall) easily entered. He used Bob, Agent Of Hydra, to locate and free Agent X (who had been turned into a 500 pound slob by Hydra's Morphogenetic Actuator), being changed back to normal size in the process ("They had Pym Particles. Who doesn't?" wink . On the Hydra plane back to the USA, Agent X asked Deadpool to take over the running of Agency X whilst he got back in shape after the effects of a Hydra device caused him to gain lots of weight. Deadpool readily agreed.
Cable & Deadpool #12
After returning to Agency X, Deadpool and Agent X found that Outlaw and Sandi had been taken hostage by T-Ray. At the Three Strikes Bar, Deadpool gathered information - using violence towards alcohol - to find out where T-Ray was. At Hillsborough (New Jersey), Deadpool, Agent X and Bob Agent Of Hydra (Deadpool's semi-replacement for Weasel who was still in Afghanistan) went to save the girls. Deadpool's first choice of farm house was the wrong one. His second choice was spoilt when T-Ray happened to be stood behind where Deadpool landed after jumping the window - and hit him with a bat. When Deadpool awoke, T-Ray beat him, whilst talking about their last encounter where he 'revealed' that he was actually Wade Wilson. Deadpool managed to break free of his duct taped chair and proceeded to beat on T-Ray - and complaining about the accompanying sound effects. He told T-Ray that "a good friend of mine, who's not any more" helped fix his brain damage - and he now knew who he was. Then T-Ray started using his black magicks. In the ensuing fight, Deadpool was stabbed by T-Ray by a magic sword - a wound which his healing factor would take more time to fix. Being forced to choose to run away, at the expense of Sandi and Outlaw's lives, or stay and save them, possibly dying in the process. He chose to stab T-Ray in the head with a katana ("forged by the same guy who made the one on Heroes" wink .
While Providence was being attacked by the space-faring entity Hecatomb, Deadpool took the Agency X jet, to help Cable (then part of the Rogue-led X-Men) against the alien. Though he arrived too late, he was in time to help Cable to fight against the Marauders. After a brief skirmish with Sabretooth where he used all of his ammunition taking apart the mutant while Irene Merryweather escaped the island. He then fought the Marauder Senyaka while Cable ran from Gambit and Sunfire, to destroy all of the future-records stored in Providence’s computer systems. Cable had sent him to get the 'Back-up copy' of the data. Cable’s final act was to send Deadpool back home with a “Bodyslide by one” just as Deadpool realised that Cable would never trust him with something so important. In the past, this brought them both to the exact same place - Deadpool was the only one who arrived in his apartment.
Deadpool went to Rumekistan to pay his final respects, and was asked by Cyclops to stop Wolverine from tearing through a Hydra base in Afghanistan. Knowing that Weasel was still there, he accepted the job from his ‘fellow’ X-Man and took Bob along with him. Finding Weasel before Wolverine (by a matter of minutes), Deadpool killed his fair share of Hydra shock troops. Weasel was now running this Hydra cell and strapped into a teleportation-capable suit, calling himself the "Penetraitor". When Wolverine turned up and decapitated Deadpool, Weasel distracted the mutant, trying to explain his plan. When that went without luck, more Hydra troops came out to attack Wolverine, dying in the process - but delaying Bob’s reattachment of Deadpool’s head. The only Hydra that were left, were strapped into suits similar to the Penetraitor’s. They activated the suits, expecting to be able to attack Wolverine - but disappeared. The Penetraitor then had the chance to explain, telling Wolverine that the reason there was an ‘I’ in his name, was because he was going to turn against Hydra. The hope was to fit them all with teleport suits, and send them to Guantanamo Bay.
With things in Afghanistan sorted, Deadpool returned to Rumekistan with Weasel and Bob to square things with Cyclops. After paying his final respects to a statue of Cable, Deadpool spoke to Weasel, asking if damage his Penetraitor suit sustained during evading Wolverine was dangerous. Just after Weasel explained that there were just a few stray chronitons, Deadpool and Bob disappeared in a flash of light.
Appearing in Europe, circa World War II, Deadpool and Bob encountered Captain America and Bucky. They aided the two while having random time-skips, to find Arnim Zola. After defeating the scientist and his creations, another time-skip made Cap and Bucky forget who Bob and Deadpool were, then try to attack them. During all this, Weasel had gone to the Fantastic Four (then including Black Panther and his wife Storm) for help in returning his friend back to this time. The equipment he used aided them in pulling the time-displaced duo closer, but not far enough. Deadpool and Bob met the original FF and chatted about the predicament, shortly before nearly being lost in a time-fault. With the combined efforts of both teams of FF, they managed to be saved.
Deadpool next went on several missions for Dr Strange, including stabbing a lot of mystical creatures with his katana. He later found out that the reason for this was because he needed to seal the mystical hole he created in T-Ray's head by stabbing him and killing him. This was done successfully, but Deadpool wasn't happy to hear that next he had to find T-Ray's soul and bring him back to life. To do this, he was sent on a vision quest by Brother Voodoo, where he fought T-Ray. After a long battle, T-Ray was eventually returned to life, with both realizing they needed each other to complement the other. Upon returning to Agency X headquarters, Irene Merryweather came asking for aid in locating a energy generator for Rumekistan which was based in the Savage Lands. When arriving, the team encountered a mind controlled Kazar, and had to fight the forces of Brain Child. During the conflict, Deadpool accidentally used Weasel's Penitraitor technology to warp some dinosaurs to the Latverian embassy in New York. The result was upon defeating Brain Child they had to return and help the Avenger's fight dinosaurs infected with the symbiotes they had just defeated. After a long battle, Deadpool saved the day by absorbing the consciousness of the symbiotes and killing himself (albeit briefly).
Despite being hailed as something of a hero after the stunt with the symbiotes, Deadpool slipped easily back into his old ways when paid to kill Wolverine. Quite possibly still being sore that the X-Man decapitated him recently, Wade agreed and set about setting things up. For once, he planned every stage of the attack. First he shot, maimed and blew up Logan, then used an AIM device to attach to a passing subway car and drag him down the street at high speed. Wade used this time to get changed and pick up some gear. When Logan got free, he was in a feral rage, something Wade had been counting on. What he wasn’t counting on was Logan to be feral-smart, cutting off the merc’s fingers seconds before he attempted to fire his gun. During the fight, a woman screamed for help next to a burning car, a baby in child-seat about to be engulfed in flames. Wolverine went to help, tearing the door open which resulted in a backdraft. Logan recovered in time for the doll baby to state it had made stinky before the timer hidden inside it reached zero. Deadpool congratulated the woman on her convincing screaming, giving her something extra over her agreed ‘fee’ to “get some headshots done.” He said it was the most amongst the most convincing screams he had ever heard, and he had heard a lot. When congratulating her on the look of mortal fear that was on her face, he realized Wolverine had partly recovered and was about to attack. Logan managed to get three claws into Deadpool’s chest, getting a dagger in return. The mutant then shoved the other three claws into the other side of the merc’s chest, Deadpool still having enough strength to lift his gun to under Wolverines chin and fire with his newly regrown finger. The two slumped against each other, neither standing nor falling.
Deadpool's healing factor proved to be faster in repairing the damage, as Wolverine found out when he awoke in a warehouse rented by Wade. He had tied Wolverine up to a mechanism above a full swimming pool, with the intention of pulling a handle and letting his adamantium skeleton keep him under water to drown. After a little banter, Deadpool went to pull the lever, getting his hand cut off before he could do so. He was surprised to see Daken stood there, but had little time to react other than telling him that 1985 wanted it's hair back, before Daken pulled the lever himself, plunging Wolverine underwater.
This angered Deadpool who then attacked Daken, whom revealed he had the uncanny ability to be exactly where an opponent wasn't expecting him to be. Upon his other hand being cut off, he realized the resemblance between Daken and Wolverine, the former revealing he was in fact Wolverine's son. During the fight, three grenades were plunged into the water and the resulting explosion flung Wolverine out of the water. Deadpool took a slice across his midsection and nearly lost consciousness as Wolverine told Daken that what was coming wouldn't hurt - just before Daken was shot in the head with a carbonadium bullet. Wolverine revealed that the sniper was Bucky Barnes, who was also the one who hired Deadpool whilst wearing a SHIELD uniform - and there was no money coming. The only way to track Daken down was for someone to try and kill Wolverine, which Deadpool may very well have done if his son hadn't interfered. Despite being told that this was the end to it, Deadpool's thoughts were plotting revenge even as his healing factor worked.
Deadpool during the Skrull invasion where his size made even Galactus jealous.
Deadpool's activities next came to light when the Skrul invasion began. He posed as the Atlanta Braves mascot, which read as a heavily armed, non-human anomaly by the Skrull ship. Who promptly blasted it. The suit was filled with para-aramid pellets that acted as heat absorption to take most of the blast's heat. He then proceeded the close the Skrull ship inside the stadium and attack them head-on when they came to investigate the suit. He hallucinated that five of the Skrull's were actually eager to get his autograph, whereas they had no idea who he was and only wanted to kill him. Two voices in his head (via caption boxes of yellow and white) argued that Deadpool himself came up with the plan, not them, thereby inferring that he has three slightly different personalities. The Skrull commander razed the combatants, Skrull and Deadpool alike, with the ship-borne weapons. Upon inspecting the mascot costume, they found it empty. They deployed their Super-Skrull (not Kl'rt, The Super Skrull), who had a mix of Iceman, Human Torch and Black Bolt's powers with Iron Man armour, to find Deadpool. Deadpool was on top of the ship, where he lowered two boxes of TNT into the cooling turbines of the Skrull ship and blew it up. He floated to the ground using a parachute, where he took in the sight of dead Skrulls, counting up their point worth with his "Pool-O-Vision™". He approached the Commander with a proposition, apparently part of his original plan. He told the Skrull he was reporting for duty.
Deadpool was escorted aboard the vessel and put before a Skrull committee. They listened to him tell his origin story before asking him to repeat, but this time speaking into the Universal Translator. Which gases him as soon as he begins his rehearsed speech, ready for transport to the Skrull's Sci-Ops division in Cheyenne Mountain, former base of NORAD. After being examined, the science chief decided Deadpool was suitable to have his DNA bound with the next generation of Super Skrull. He was given the go-ahead and Deadpool was strung up to await execution. A day later, the science chief ordered his death - but was told to wait by Deadpool himself. He claimed the new Skrulls would certainly be able to heal like him, but without being trained by him, they would not be as effective at getting things done. He offered his hand to shake to seal the deal to help each other - much to the surprise of the geneticist. After saying he'd gotten free thanks to an ancient Chinese secret, they shook hands. And Deadpool laughed, worrying the Skrull - but excusing himself and saying to get to work.
The first thing he chose to do was use the Next Gen 'Deadpool-Skrulls' to fight five to one odds against the current batches of Super Skrulls. His Skrulls won, much to the anger of the science chief. Deadpool explained that the only way to beat the Earth's heroes was using his method: Madness. He then proceeded to carry on teaching the Next Gens how to do things his way, ending with them all telling a 'Knock knock' joke that has a headshot as a punchline. The science chief gives the order to send in a Purge Unit to dispose of the Next Gen's. Whilst the two sets of Skrulls battle, Deadpool has made himself scarce. The Super Skrull from the stadium finds him communicating with Nick Fury, and hallucinating again. When Deadpool came out of it, he admitted that he was a traitor, though only to the Skrulls - not to Earth or America. Then ran. On the way to come up with a plan, he argued with the voices in his head before he finally got an idea. He got into the sewer system and managed to anger the Super Skrull enough to get caught in the flow from a burst water pipe. When the science chief caught up with Deadpool, he had the Next Gens under control and ordered them to attack Deadpool. Deadpool was happy to inform the Skrull about his healing factor being engineered specifically to him, taking his cancer into account. So the Next Gens bodies would continue to manufacture replacement cells, despite not continually losing any, until "Splorch". He then beat the geneticist to death and went back to the communication console. He apologized for taking so long and proceeded to go through with Fury's plan and upload Skrull bio data to him. He tapped in the key sequence and the data transmitted - being intercepted by Norman Osborn.
Deadpool, finding himself unemployed and unpaid for his past two jobs, got fed up after building a semtex chair. He decided to seek out the one person he reckoned could give him paying employment. He called up an old 'friend' Colonel Zeke, and was told there was something he could do. Go to Eastern Europe and kill Doctor Druek Lovosno, who turned Zeke's wife into a zombie. Further information led Deadpool to the right town, where the doctor was making people young and beautiful for a high price. This meant them eating human flesh. Deadpool was to find the wife and kill the doctor. Upon reaching the footpath to the castle, he was met with a humpback, who gave him a questionaire to fill out, seeming to believe Deadpool wished to be a patient of the doctor. He also gave Deadpool a bottle of water whilst he did so. Two hours later, Deadpool finished and had a drink. He then actually looked at the label and saw it was in fact poison. He awoke in what he thought was a BDSM session, mostly nude and shackled in place with Zeke's wife stood holding his pants. After trying to explain that Zeke had sold him down the river, as a renewable food-source for the zombie's, the doctor came in and did it. The zombie nurses began to eat him, only to find it disgusting - tasting artificial and foul. Instead of opting for incineration, Deadpool managed to broker a deal with Lovosno to get a large supply of food for the zombies. He got released and contacts Zeke, who comes to pick up his wife - with over thirty mercenary's accompanying him. Upon revealing that he will didn't intend to pay, Lovosno and his zombies attack. Just as they are tearing each other apart, Deadpool let. Upon exiting the gates, he pressed the detonator for his former semtex-chair, which he had distributed around the castle.
After the third unpaid job in a row, Deadpool had to steal passage on a freighter bound for America. He didn't dock, however, Tiger Shark tearing through the hull. He awoke on a beach in Mexico, badly hurt, missing an arm and with his costume in tatters. He spent the next twenty-four hours in a homeless shelter, which he exited hoping to find and kill Tiger Shark. Tiger Shark however had just found Deadpool, and tried to kill him with an oversized machete. Deadpool ducked back into the shelter with the intention of still killing Tiger Shark, but doing so to impress the shelter's nurse. He was unsucessful, only drawing police attention. He was then shot dead by the police when Tiger Shark ran. He awoke later to find himself on a pier in a body bag, unlike every other time he had unzipped his own body bag - in a morgue.
Deadpool and Bob, Agent of Hydra
Tiger shark leapt out of the water and tried to slice off Deadpool's head again, only to be shot at by a man shouting "Hail Hydra!". Bob claimed he was saving Deadpool, only to be hit into the water. Deadpool followed, only to go after the rifle Bob was holding. Bob resurfaced after Deadpool had, and was waiting for Tiger shark to surface for air. The two left to sleep in a motel. When Bob woke Deadpool, they discussed strategy whilst Wade ate at least half a dozen taco's. Needing drink, he went to leave the room only to hear Bob c**k his rifle. He turned to be told that, so long as he promised to promise not to kill him, Bob would let Deadpool live. Deadpool revealed that he knew all along that Bob was sent to kill him, and that he had removed the bullets from the gun - and Tiger Shark was heading down the hallway towards them. He then went into the bathroom, wanting to get the drop on Tiger Shark. Which worked for all of a few seconds, as as soon as Deadpool had Tiger Shark dead to rights, Bob distracted his friend accidentally. After a struggle, Deadpool shot Tiger Shark through the motel window, then demanded Bob tell him the identity of the man who sent Tiger Shark and Bob after him. Bob revealed it was Norman Osborn. When asked who on Earth that was, Bob turned on a television to show the savior of mankind from the Skrull's Secret Invasion.
Deadpool traveled back to New York and attempted to break into the Avengers tower, only to fall into a trap set up by Osborn, in which Deadpool "accidentally" got his hands on a teleporter, giving Osborn's Thunderbolts the location of his base. There he contacted Taskmaster and convinced him, with money, to help with a scheme. Whilst Taskmaster was on his way, Wade managed to disable all of the Thunderbolts, bar Black Widow - whom he asked if she had a boyfriend at gun point. Faking an interest, Black Widow closed the gap and kneed him in the groin, an act that only injured herself. Wade had a gun in his pocket - plus was happy to see her. Much to his surprise, that joke made the Russian femme smile. Their meeting was interrupted by Paladin firing at Wade. He teleported to Taskmaster's 'Unoccupied office building' where he regrouped and got the bullets out of his body whilst talking about how much he adores Black Widow. There, he concocted a new plan which involved there being two Deadpool's.
Deadpool hired a single-propeller plane and flew it over New York trailing a banner saying "BW <3's DP? Call 212-555-4685". Black Widow did so upon seeing it, tracking the location of the call connection. It was picked up by Taskmaster, who claimed the line was bad and hung up, having gotten the location of the Thunderbolt's HQ. As the Thunderbolts left in an Oscorp van to go to attack Taskmaster's position, Deadpool fired upon them whilst chatting to Black Widow, whom he had called back. He kept trying to flirt with her whilst firing from the plane, but dropped the phone before crashing into the bay. He teleported to Taskmaster before he got too wet, getting his phone before calling Black Widow back. He then teleported to her and she tried to kill him, in the process getting kissed by the merc, done because he claimed he loves her. When the Thunderbolts reported that they were returning to her, Deadpool teleported again to Taskmaster, wanting someone to stall the group whilst he spent time with Black Widow. After losing Rock-Scissors-Paper, Deadpool was left taking care of the Thunderbolts whilst Taskmaster went after Black Widow. When Deadpool ran, Taskmaster convinced Black Widow to get into the Thunderstrike jet, he was sealed inside and gassed. By the time Deadpool got back to Taskmaster, Headsman was about to cut his head off. Deadpool shot the chains holding Taskmaster, allowing his double to join the fight. Deadpool went after Osborn, who had attended the decapitation and was running away in a quinjet. As he was contacting his aide, Deadpool came up behind him and told Osborn that he owed him. Osborn leapt at Deadpool, getting shot in the process, and beat his head against the floor. The quinjet crashed due to Osborns negligence, giving Deadpool a chance. He wasn't able to take it, Black Widow then shooting him through the heart. Deadpool took the chance to begin singing. Headsman stopped that by cutting off Deadpool's head.
Move along Green Lantren, here's the Deadpool Corps
Later, Deadpool was paying Taskmaster out of an ATM, having stolen Osborn's wallet. He thanked his friend to sewing his head back on, to which Taskmaster claimed innocence. Deadpool happily announced that Black Widow must, in fact, love him back as she did it.
Whilst Osborn was on a chat show, soon after, Deadpool teleported behind him holding a sign saying "Respawn lol" on, as Osborn thought the merc was dead. Deadpool was so desperate for money, that he was posting for jobs on Craigslist. One of which made him break into a gentleman's home and order a pizza. He was actually after the pizza boy, his employer wanting retribution for a childhood nickname he cruelly gave her. Deadpool shot the delivery boy then, as an act of kindness, let the home-owner tell the police he was robbed - by getting him to load all of his possessions into his car. When he was almost finished, Deadpool turned on the television to find a newscast about when he temporarily joined the Skrull army, denouncing the mercenary as a traitor to the human race. Seeing this as a besmirching his name, he went to find the man to get the car keys. He found him with an arrow buried in his chest. Deadpool spoke as if he thought it was suicide, but he was ready for an attack by Bullseye, now dressed as Hawkeye as part of Osborn's Avengers. At first Deadpool thought it was actually Hawkeye, but after a scuffle, he came away with the man's mask and bow. But lost his teleporter. Another brief scuffle ended in Deadpool receiving an arrow through the skull. Having thought that Deadpool is dead, Bullseye plannning on grinding up Wilson into hamburger meat, but underestemates the healing factor which heals Wade around the arrow, leading to another fight ending with a meat hook through Bullseye's chest; severely injuring Bullseye in the chest. Bullseye paid Deadpool money to never speak of this again, with which Deadpool bought a boat. After a failed venture in piracy, Deadpool decided that he would be a hero and raced toward the mutant haven Utopia to become an X-Man. Though they rejected him, the X-Men realized that Deadpool was too loose a cannon and put Domino on him under the guise of a probationary membership. Deadpool decided to get in the X-men's good graces by killing Mark Kincaid, father of Mercury, who had been claiming that the X-Men had kidnapped his daughter and were holding her against her will (at the behest of Norman Osborn (Earth-616)). Osborn attempted to use the situation to further discredit the X-Men by killing Kincaid and blaming Deadpool (who had publicly and falsely claimed X-men membership), but Deadpool had set everything up to make the X-Men heroes again in the eyes of the public.This allowed the X-Men to reluctantly give Wade full membership ever.
He seemingly stayed on Utopia, and squatted Loa's quarters during Necrosha. When Loa was attacked by the Cortez, Delgado and Mellencamp, who were searching Magneto to kill him, Wade first intended to team-up with them, unknowing that Magneto was now an X-Man but was soon asked by Cyclops to battle them, without killing. He quickly realized (in disobeying) that wouldn't be a problem as the Acolytes were regenerated by the T-O virus. Severely beat up, he was saved by Loa, which powers revealed to be fatal to the returned, and Deadpool then used her as a projectile on them.
Deadpool was recruited by an entity known as the Contemplator to save the Multiverse. To do this he would have to assemble a team of alternate universe Deadpools. He visited a string of universes where his alternates were significantly different from him, recruiting Lady Deadpool, Kidpool, Dogpool, and Headpool along the way. With his team assembled, he revealed his plan to save the multiverse to them.
Deadpool joined Wolverine and Archangel's Black Ops X-Force team to proactively eliminate threats to the mutant race with the only rule being that no one, not even the X-Men, could ever know that they exist. After one of their first missions, which ended with the team killing Apocalypse, who was reincarnated as an innocent child, Deadpool called a meeting to discuss his moral doubts about killing a child. During this meeting, Archangel told Wolverine that, despite being employed by Archangel for over a year, Deadpool never cashed any of the checks for his services. Later, in the Deathlok team-up, X-Force was taken into The World to look for the origin of the mind-controlled army. There was also some bad tension between Deadpool and Fantomex, which leads to them going different ways. Deadpool ends up being the one to kill the world Father by cutting his head off then putting a sword through it to show the rest of the team. Fantomex is surprised, and they leave in silence.
During the invasion of the Serpent and his Worthy, Deadpool attempted to cash in on the fear that was running rampant throughout the world. To this end, he stole a magic hammer belonging to a pair of werewolf hunters, and then gave it to the dimwitted Walrus, convincing the hapless Mort that he'd been chosen to serve as one of the Worthy. His plan was to send the Walrus rampaging through the town of Cimarron, New Mexico, and then show up and "rescue" the town and collect a hefty fee. The hammer, however, proved to have the ability to negate Deadpool's healing factor during a full moon, and what should have been an easy fight proved nearly fatal. Initially, he tried to run away, but was confronted by the werewolf hunters, who informed him that the hammer was needed to stop an impending attack by a pack of werewolves. Convinced of the necessity of retrieving the hammer, Deadpool returned to town, and tricked the Walrus into entering the sheriff's office, thus taking it out of the light of the full moon and deactivating its powers. He then promptly shot the Walrus in the shoulder, took back the hammer, and effectively saved the town, though he found to his dismay that the town's cache of Confederate gold had long ago been stolen, and thus they could not pay him for his efforts.
The Best There Is
After defeating the intergalactic mercenary, Macho Gomez, Deadpool went in a space odyssey where he saved two civilizations (the Urrulians, and the remains of the Ongulians) and killed Id, the Selfish Moon of Ego. After coming back to Earth, he fought the vengeful Blind Al, Weasel, Taskmaster, Big Bertha and Sluggo, under the leadership of Macho. After a drawn out fight and killing Sluggo, Wade paused and asked his so-thought friends "Is this what you want?!" After which they proceeded to shoot him until he lost consciousness. Thanks to his healing factor, Deadpool recovered. After talking with Bob about how he treats his friends, Wade realizes what he truly wants is to die.
Deadpool in Crossmore.
Unsuccessfully committing suicide, surviving atomic bombs, and battling the Hulk, Wade is sent to the English prison of Crossmore, where he meets doctor Ellen Whitby, who had been secretly obsessed with him for several years. Out of a one-sided love, she helped him escape. Despite this, Wade rejects her for being completely insane. After leaving he is encounters the local law enforcement which inadvertently leads to Wade taking the Queen of England hostage. After having a talk with the Queen, she convinces Deadpool that Whitby is his responsibility. After going to her apartment, he finds many of his own severed body parts in the fridge. After confronting Whitby she kills herself, and Wade throws the frozen body parts in a dumpster and leaves. Afterward, the parts thaw and heal together to form an even more deformed and very sadistic clone of Deadpool.
Both Deadpools managed to get to New Jersey on their own. Wade met Evil Deadpool at his favorite chimichanga restaurant, which Evil Deadpool blew up. After a long fight and running out of bullets, the Deadpools agree to meet and fight at Canarsie Park. After another fight and another explosion, Evil Deadpool escapes while Wade is confronted by Captain America and then escapes. Meanwhile, Evil Deadpool goes to Mister Negative to ask him for a job (murdering a police chief's children). After careful contemplation of Evil Deadpool's next move, he decides that his motivation must be to one-up the original Deadpool. After some planning, Wade proceeds to publicly kidnap a random child in hope that this would draw out Evil Deadpool.
However, Evil Deadpool had already predicted this and kidnaps the police chief's children and sends a message to the parents that he had done so (leading to the chief to believe the real Deadpool had kidnapped his children), and then takes out Captain America who had been watching Wade (and knew that Wade was never anywhere near those children). After Cap recovers and Interpol becomes involved, Cap informs the chief that Deadpool couldn't have kidnapped his children and so all are led to believe he has an accomplice. After some time passes, Wade realizes that he has been played, frees the child and escapes. Using a teleportation device, Evil Deadpool lures the police chief and Deadpool into a trap to make it appear that Deadpool had killed the chief and his children, this fails however and the chief escapes with his children. Evil Deadpool then explains to Wade that his motivations were to show him that no matter what good he accomplishes people will only ever see him as a monster.
Just then, Captain America and the police arrive at the scene and tell both to stand down. Evil Deadpool raises his weapon at them and is shot down in a hail of bullets. After he is down, it is seen that he was hit with a special dart that none of the police claim to have fired, and all of Evil Deadpool's scars fade until he appears a regular human and dies. After witnessing that there is a way to kill him, Wade steals Evil Deadpool's teleportation device and escapes.
Search for death and powerless
Wilson started a plan to get the serum used to neutralize Evil Deadpool's healing factor, so he could finally be with his beloved Death. With the help of Bob, he manipulates X-Force, the Kingpin and the Hand, Daken and Tombstone (who had the serum made in the beginning). Deadpool pitted X-Force against Typhoid Mary and the Hand (believing Kingpin was in possession of the serum). Meanwhile Daken stole a sample of the serum from Tombstone which he later used to shoot Wolverine.
In the midst of the chaos, Deadpool was injected with another sample of the serum by Bob (which he got from Tombstone after conspiring with him against Wade), who was then angered after finding out that Wade had planned for this all along. Wade then went to X-Force to learn that the serum was made specifically for his DNA, and thus had no effect on Wolverine. After learning that everything was planned by Wade, X-Force too was angered and decided to kill Wade after he had escaped from them. After fighting and escaping from Tombstone, Wade was confronted by an angry Bob. After this (and seeing that his deformities were cured by the serum) Wade resolved not to die. Later, the two confronted X-Force. After making amends, they let Wade leave to help the injured Bob.
After he lost his healing factor, Wilson claimed he felt "more alive than ever." However, after a harsh beating from Intelligencia Wade realized that he had let his ability to heal compensate for skill so he decided to ask for help with Taskmaster in training. Taskmaster asked Wilson to help him steal Pym Particles from S.H.I.E.L.D., but actually he allowed Black Box to study Wade in order to prepare his vengeance against Wilson, even letting him know Deadpool lost his healing factor.
Wade managed to defeat the villains recruited by Black Box, Black Tom and Black Swan, but in the process his face was burned and disfigured again. Former FBI agent Allison Kemp wanted to get revenge on Deadpool because of his involvement in an accident which left her in a wheelchair, and she called other nemeses of Deadpool such as T-Ray and Slayback and trained them in order to kill the merc. Deadpool infiltrated their base and managed to get T-Ray and Slayback killed. When Kemp was about to kill herself in a explosion, which would also kill Wade in the process, he convinced her not to. In that moment, he was surprised by the returned Evil Deadpool, who informed Wade that the serum they took was not permanent, the reason why Wade's face didn't heal or a finger he lost grew back, so Wade would return after Evil Deadpool shot him.
The Good, the Bad and the Ugly
After being hired by S.H.I.E.L.D. to destroy zombie presidents, the magician Michael, who unintentionally caused the zombie attack, transferred the mind of S.H.I.E.L.D. agent Emily Preston into a portion of Deadpool's brain in order to prevent her death.
Later, Deadpool was abducted to North Korea by the Butler. The Butler revealed to Wade their shared past, and also that he had taken Deadpool's lost daughter, Eleanor, prisoner after Wade quit his program. With the help of Preston's consciousness, Captain America, and Wolverine, Deadpool managed to free all the prisoners from the North Korean camp, as he also killed the Butler. Although his daughter could be alive, Deadpool decided not to try to reach her, in order to prevent himself from ruining her life.
Shortly after placing Preston's consciousness into a LMD modeled after her, Deadpool was hired by Dracula to deliver his future bride to him while fighting various demonic creatures. This bride was Shiklah, the evil queen of the undead. Though the two fought, they eventually got engaged, effectively stealing Dracula's bride, and later married.
Shortly after, Deadpool managed to track down and reunite with his lost daughter Ellie Camacho.
As part of his plan to stop the recently-unleashed Red Onslaught, Magneto recruited Deadpool into an army of super-villains to help the heroes fight the Onslaught in Genosha. This team successfully turned the tide of the battle against the Red Onslaught and his Stark Sentinels in favor of the heroes, and allowed the Scarlet Witch and Doctor Doom to cast an inversion spell to alter the axis of the Onslaught's brain.
However, the spell affected all those present in the island, including Deadpool, who had his pacifist personality take control of his mind and body, and become the Zenpool. When Wade discovered Evan Sabahnur had become Apocalypse and was planning on detonating a gene bomb to kill everyone who wasn't a mutant on the planet, Wade tried to convince him into becoming good again, and also helped the Astonishing Avengers stop the inverted X-Men.
After much effort, Wade managed to convince Apocalypse into helping him prevent the Axis from killing the White Skull (the inverted counterpart of the Red Skull). After Doctor Doom and the Scarlet Witch managed to cast a reinversion spell, Wade returned to his Deadpool persona. However, as an after effect of the reinversion spell, Wade regained his conscience.
In retaliation for destroying their helicarrier and slaughtering countless agents, U.L.T.I.M.A.T.U.M. tried to have revenge by killing Deadpool's family and friends. After their attempt failed, Wade put together a plan to deal with U.L.T.I.M.A.T.U.M. once and for all, successfully retaliating and murdering all of U.L.T.I.M.A.T.U.M.'s agents. Subsequently, Wade decided to give up his life as Deadpool. As he was celebrating the start of a new life with his friends and family, an incursion between Earth-616 and the Earth-1610 caused the collision and destruction of both universe's planets Earth, with Deadpool and his allies dying in the process.