"It's dangerously cold," Washington Mayor Muriel Bowser told CNN's "The Situation Room," warning that the nation's capital was bracing for up to 8 inches of snow. And federal government offices in the area will be closed on Tuesday.
But the snow isn't the only thing to worry about.
"We are going to see high snowfall amounts, but the ice is what is going to be the big story," CNN meteorologist Jennifer Gray said, pointing at North Carolina.
Raleigh, North Carolina, could see up to a half-inch of ice, which could knock out power and "makes travel nearly impossible," she said.
The bitter cold is coming from several fronts. This weekend, the Northeast weathered its fourth snowstorm in three weeks, and extremely low temperatures are predicted to hang around for two more weeks.
A winter storm stretching across the Midwest and Southeast is bringing freezing rain and ice accumulation, especially from Arkansas to Tennessee.
Late Monday, Tennessee declared a state of emergency as road conditions quickly deteriorated and power outages spiked.
Temperatures across the eastern half of the United States will be below average for the entire week, and that's a big deal as winter fatigue sets in.
In Boston, where 95 inches of snow have already been recorded this year, the latest storm was expected to skirt by and bring a few more inches, Gray said.
This February is the city's snowiest month ever.
Frank Ippolito, the owner of a snow removal business operating in Boston, said his staff was weary from lack of sleep.
At this point, his snowplow drivers are putting snow "anywhere and everywhere there's an open piece of land that won't obstruct the view safely of the driver or prevent someone from getting out of a doorway or moving a car," he said.
Boston Mayor Marty Walsh said one man died after suffering a heart attack while shoveling snow.
"Please stay close to your home today -- shovel in short stints," he said.
Mounting "snow rage" is pitting drivers and neighbors against each other as the winter weather shows no sign of letting up, CNN affiliate WFXT reported.
"We've been noticing a little frustration out there on the roads," Massachusetts State Police trooper Kathryn Downey said. "I think people are getting pushed to their limits."
Margo Souza of Charlestown, Massachusetts, told CNN's iReport she was trying to take the snow in stride, even though it has doubled her commute. Her golden retrievers, Logan and Copley, love to bound around in it.
Still, she said she was hoping her city's baseball team might bring something with them when they head south for spring training.
"Send the snow to Florida," she said, "along with the Red Sox equipment."
One New York resident, Max Guliani, posted photos on Twitter of the frozen fountain at Bryant Park in New York City.
A pipe burst at the city's iconic Empire State Building, forcing one of its observatories to shut down, a spokeswoman said.
In Ithaca, in upstate New York, temperatures have gotten so cold that even the city's tourism website is telling people to head to the Sunshine State.
"That's it. We surrender," the website says. "Winter, you win. Key West anyone?"
It's cold outsideAs a weary Northeast remains buried in snow, the South and Midwest are gearing up for a messy mix of snow, sleet and ice.
Snowfall records have been broken in the Northeast, and now, more than a dozen other states, stretching from Kansas and Oklahoma to North Carolina and Virginia, are bracing for inclement weather.
"It's been about 10 years since we've had something this significant," said Doug Hamilton, chief of public services in Louisville, Kentucky.
In Lexington, plows are working around the clock, Mayor Jim Gray told CNN affiliate WLEX.
Already, he said, parts of the city have seen between 6-11 inches of snow, which he described as "very unusual."
Southern Indiana could see up to 10 inches of snow, while northern Kentucky faces between 8 and 14 inches, the National Weather Service said.
"Travel will be treacherous with some roads nearly impassable," the National Weather Service warned. "Have an emergency kit of blankets, food, water and flashlights if you must travel."
In addition to slick roads, trees may come down because of snow accumulations, causing power outages. Forecasters warned residents in affected areas to defer travel on rural roads until Tuesday.
Alabama Gov. Robert Bentley ordered various agencies on alert, including the Emergency Management Agency, the state National Guard and law enforcement agencies.
"State agencies are on standby to coordinate resources to support the needs of Alabama counties if necessary," he said.
In Missouri, St. Louis braced for heavy snow Monday, possibly into overnight, CNN affiliate KMOV reported.
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