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Dihydropyrimidinase-like 3 (DPYSL3), a member of the TUC (TOAD-64/Ulip/CRMP) family, known also as CRMP-4 or TUC-4, is involved in neuronal plasticity and neurite outgrowth and extension [1], [2] and [3]. The DPYSL3 interactions with structural proteins such as tubulin, actin, and also chondroitin sulfate proteoglycans, which are structurally and functionally important components of the extracellular matrix of the central nervous system, suggest that this protein may play a role in the regulation of Artemether organization [4] and [5]. Regulation of the cytoskeleton is involved in basic cellular activities such as cell–cell interaction, exo- and endo-cytosis and cell adhesion and migration [6] and [7]. The precise synchronization of cytoskeleton organization is crucial for growth cone navigation, the process underlying the formation of neuronal connections.
The 43 kDa growth-associated protein (GAP43), also known as B50, neuromodulin and F1, plays an important role among the proteins involved in the regulation of neurite outgrowth, growth cone guidance and synaptic plasticity [8] and [9]. Its expression in neurons correlates with axonal outgrowth and the establishment of neuronal connections [10]. It is known, that within the cells, both GAP43 and CRMP family members (CRMP-1, -3, -5, and -4) accumulate in detergent soluble, cholesterol-enriched lipid rafts at the inner surface of the cell membrane [11] and [12].