Welcome to Gaia! :: View User's Journal | Gaia Journals

Interestingly, we found that the two transgenic mouse lines carrying the 230E8-YAC showed a weak significant increase of the longitudinal axis of the total Sorafenib (p = 0.03), compared to euploid littermates in adult mice ( Fig. 1). This increased length corresponds exclusively to a high significant increase of the antero-posterior axis of the cerebellar vermis (p = 0.001) ( Fig. 1).
Fig. 1.
Figure optionsDownload full-size imageDownload as PowerPoint slide
To better characterize this new neuroanatomical phenotype, we measured the area of each cerebellar lobule in longitudinal sections at the midline of the normal and transgenic adult cerebellum (Fig. 2). We detected a hypertrophy of the rostral part of the vermis, with the anterior lobules (II–VI) of 230E8-mice showing a high significant increase of their area (lobule II–V, p cells (arrows) showing no differences between normal (B) and transgenic (D) mice.