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The tooth sections were examined
In the second experiment, the time between injection of S661/vehicle and insulin/vehicle was either 360 min or 10 min.
Results and discussion
Fig. 1.
All PF2341066 curves described under Results and discussion. The corresponding IC50 values are listed in Table 1. (A) SPA competition assay of 125I-HI from HIR A. (B) SPA competition assay of 125I-HI from HIR B. (C) SPA competition assay of 125I-IGF-1 from IGF-1 receptor. (D) SPA competition assay of 125I-IGF-1 from type A hybrid receptors. (E) SPA competition assay of 125I-IGF-1 from type B hybrid receptors. (F) PEG competition assay of 125I-HI from HIR B. (G) PEG competition assay of 125I-HI from rat insulin receptor type B. (H) PEG competition assay of 125I-HI from pig insulin receptor type B.
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Table 1.
Affinity of human insulin, IGF-1, S661, and S961 for various receptors
IC50 (mol/l)HIR-AaHIR-BaHIR-BbHIGF-1RaA-hybridaB-hybridaRat IRbPig IRb
Human Insulin2.9 ? 10?112.2 ? 10?111.7 ? 10?112.1 ? 10?92.1 ? 10?92.7 ? 10?92.7 ? 10?112.2 ? 10?11





 
 
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