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In the male rockfish, TBT exposure elevated the RXRα expression. Exposure to 1 ng L−1 of TBT resulted in a significant (p = 0.009) increase (by 1.59-fold), whereas 10 and 100 ng L−1 of TBT did not significantly affect RXRα Calpain Inhibitor II compared to the control ( Fig. 3A). The opposite pattern was observed for female rockfish, where the RXRα expression was decreased in a dose-dependent manner compared to the control. Exposure to 10 and 100 ng L−1 of TBT resulted in significant (p expression of PPARγ was observed in both male and female rockfish ( Fig. 3B).
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Fig. 3.
Retinoid X receptor α (RXRα) and peroxisome proliferator-activated receptor γ (PPARγ) expression in the brains of rockfish (Sebastiscus marmoratus) exposed to tributyltin (TBT) (0, 1, 10, or 100 ng L−1) for 48 d. (A) RXRα; (B) PPARγ. The Figure shows the mRNA levels normalized to the levels of β-actin (mean ± S.E., n = 6). Means of exposures not sharing a common letter are significantly different at p