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Sarif Industries is a moderately-sized but extremely advanced biotechnology company based in North America, with its headquarters in the city of Detroit in 2027.

Founded by the philanthropist David Sarif in 2007 when he acquired a failing Detroit auto factory and repurposed it for the automated manufacture of prosthetics, Sarif Industries specializes in the design and manufacture of advanced mechanical augmentations for human implantations. The company distinguishes itself from its competitors by working with clients to create progressive, forward-thinking, custom augmentations that answer specific challenges and needs. It strongly believes that the research, development and implementation of augmentations is a measure of human advancement towards a better, stronger, faster and smarter future.

In 2009, the U.S. Government, stretched thin by two Mideast conflicts, awards the contract of the Recycle Military Bill, financing free prosthetics for any wounded veteran who re-enlists, to the Sarif Industries which becomes the number one prosthetics manufacturer in America.

On November 30, 2010 Sarif announced the launch of the Eye-Know Retinal Prosthesis capable of restoring sight to those with a once incurable optic nerve damage and other visual impairments. In 2017, in an attempt to catch up to the rapid advancements of rival nations, the U.S. military awards Sarif a top secret no-bid contract to manufacture intelligence-enhancing chips.

In 2026, in response to increased level of competition and shrinking marketplace, Sarif realizes the need for an all-new, high-level security team to protect its research and employees. A team is formed and implemented, featuring highly-trained personnel and a veteran leader in ex-SWAT member: Adam Jensen. In 2027, members of the anti-augmentation group Humanity Front protest against Sarif's augmentation program, infront of the Sarif Headquarters in Detroit.