Mei is a cheerful person who is almost always smiling regardless of what she is saying, such as when promising to kill someone. She is, however, usually kind, speaking well of others and attempting to avoid conflict. Mei proved to be more open-minded than the other Kage, as she had shown respect and was willing to listen to Gaara; even at one point defending him from the Tsuchikage's disrespectful behavior. Mei also can be very flirtatious, as she considers Sasuke and all other male Uchiha to be very good looking. She expressed regret that she must kill someone as handsome as Sasuke, but would give him a kiss before that.
She seems to be somewhat self-conscious when it comes to her love life, as shown when she misheard Ao say that she was "past marriageable age", and threatened to kill him for such an "insult". This seems to be a running gag, as she has made similar mistakes on multiple occasions. She also seemed to be a little disturbed when Karin called her an "old hag", and beat up Ao while Fū possessed his body and insulted her.
Mei is capable of using the earth, fire, and water natures, and has two kekkei genkai. The first, by fusing earth and fire elements, allows her to use lava release ninjutsu, such as spitting out lava. The second, by fusing water and fire elements, allows her to use boil release ninjutsu, such as releasing a corrosive mist that can burn away anything it touches. It even managed to burn through Sasuke's Susanoo. She has suggested she has the ability to alter the potency and acidity of the mist created by her boil release techniques and she is apparently not affected by the mist herself.
Both Mei and Chōjūrō travel with a team of elite shinobi tasked with guarding the daimyō. She explained to the Frost Daimyō their defence plan, where the daimyō would travel between five separate hideouts at regular intervals as well as being guarded by some of the Shinobi Forces' most powerful ninja to keep them safe.
Black Zetsu continues his chase after the daimyō and when he was about to attack them, Mei quickly counters his assault with a kick. The Black Zetsu prepares to fight her but she tells him that she's not the only one he will have to defeat, but her entire team as well.