Peritoneal mesothelioma is less common than pleural mesothelioma, accounting for about 500 cases of the annual 2,500 mesothelioma cases seen annually in the U.S. Both peritoneal and pleural mesothelioma, as well as the even rarer pericardial mesothelioma which attacks the lining around the heart, are caused by inhalation or ingestion of asbestos dust.
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Cisplatin chemotherapy is effective alone; however sometimes a combination of cisplatin and pemetrexed chemotherapy is also given for malignant pleural mesothelioma. Some more treatment options for mesothelioma cancer are immunotherapy, heated intraoperative intraperitoneal chemotherapy, multimodality therapy and other clinical trials. Men are typically affected more, because of the common presence of asbestos in industrial settings.
Without an understanding of how asbestos could get into the peritoneum exclusively, and a detailed social history of all patients to rule out asbestos exposure, the link between asbestos and peritoneal mesothelioma remains merely a working hypothesis. To successfully rid the body of cancer, you must either completely remove or kill all cancer cells; typically done through surgery, radiology, or chemotherapy. Each of these methods has its limitations; not all cancers respond to chemotherapy, some parts of the body can't take radiation, and sometimes surgery just isn't feasible.
The analysis of peritoneal fluid revealed mesothelial cells with a slight atypia and some small groups with papillary configuration; there was no evidence of epithelial cells with malignancy. The histology of the peritoneal surface revealed a papillary neoplasia consisting of fibrovascular cores covered by a single layer of bland cubic cells. The patient is a female, 44-year-old at the time of diagnosis, nonsmoker, history teacher, without any known history of asbestos exposure.
