Keywords
Monocyte; Migration; Chemotaxis; Adhesion; Fluorochrome; Calcein AM; DMSO; Growth factors; TGF-β1; fMLP
Cell migration is crucial for many physiological and pathological conditions, including embryonic development, tissue regeneration, and tumor growth. The study of cell (patho)physiology has been facilitated by the development of migration assays within the last few decades [1]. Cell migration of human circulating MK 0518 can be analyzed ex vivo in so-called migration filter assays [2].
Peripheral blood monocytes are a subpopulation of circulating leukocytes. After release from the bone marrow, they circulate for several days in the blood before entering the tissue where they are transformed into tissue-resident macrophages. Monocytes contribute to host defense as well as tissue remodelling and repair [3]. As monocytes are important mediators of vascular growth [4], their functional integrity is a prerequisite for adequate collateral development. Monocyte migration can be stimulated by different cytokines and chemokines. Evaluation of (impaired) monocyte chemotaxis might predict the ability of these circulating cells to contribute to tissue repair and collateral growth [9].
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