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To investigate the adaptability of α-actinin-3 levels in skeletal muscle, adult rats were tail-suspended for 30 days. Numerous studies have demonstrated that hindlimb unloading causes the transformation of JDTic fiber types from slow to fast, especially in muscles that work against gravity [13], [14], [15], [16] and [17]. Fig. 1 shows that in this study, the suspended (S) animals displayed typical adaptations to tail suspension, i.e., lowered body weight (P myosin heavy chain (MyHC, Fig. 1C) isoforms revealed that the soleus muscles of S animals had a significant lower percentage of type I MyHC isoform (P