In conclusion, several lines of experimental evidence in this ACT-132577 work demonstrated that saxatilin suppresses the ovarian cancer cell invasion by modulating the balance between MMP-9 and TIMP-1. Functional mechanism of the disintegrin to suppress the cancer cell invasion was revealed to be mediated through integrin αvβ3 by up-regulating TIMP-1 and down-regulating MMP-9 at transcriptional level. Further investigation with the disintegrin will provide useful information for understanding the molecular mechanism of integrin signaling associated with cell motility during cancer progression.
Acknowledgments
This work was supported by the Korea Science and Engineering Foundation (KOSEF) grant funded by the Korea government (MEST) (No. ROA-2004-000-10297-0), KIST Grant (2E20060-07-180), and Research Funds of the National R&D program (Project No. 0420210-3) from Ministry of Health and Welfare in Korea. O.-H. Jeon and H.D. Lee are bladder fellowship awardess by Brain Korea 21(BK21) programme.
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Immunohistochemistry and assessment Antibodies used were as follows IL goat
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