Acknowledgment
We are indebted to Prof. Agata Karowicz-Bilińska for the help with collection of blood samples.
Keywords
DJ-1; Mitochondria; Parkinson’s disease; Complex I
Introduction
Reduced activity level and reduced amount of mitochondrial complex I have been reported in PD patients [17], [18], [19], [20] and [21] and in animal models [22] and [23]. These findings indicate that the function of mitochondrial complex I is related to the onset of PD. DJ-1 is located both in the MG132 and nucleus [1] and has recently been shown to be located in mitochondria [11], [24], [25] and [26]. It has also been reported that some parts of DJ-1 were translocated into mitochondria after cells had been subjected to oxidative stress to protect cells from oxidative stress-induced cell death [27], [28], [29] and [30]. The exact localization of DJ-1 in mitochondria, inner membrane, outer membrane or intermembrane space, is, however, still not clear, and the characteristics and function of mitochondria-resident DJ-1 are still not known.
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