OR
4) In a patient with classic symptoms of hyperglycaemia or a hyperglycaemic crisis, a random plasma ITF 2357 ≥200 mg/dL (≥11.1 mmol/L)
a
In the absence of unequivocal hyperglycaemia, criteria 1–3 should be confirmed by repeat testing.
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Type 2 diabetes (T2DM)
In the pubertal age group, T1DM must be differentiated from T2DM. A Canadian population-based surveillance study of non-type 1 diabetes in children under 18 years of age found an incidence rate of 1.55/100,000/year.10 The aetiology of T2DM is multifactorial, but key factors include genetic predisposition (>80% have a positive family history), ethnicity (more common in African-American, Asian, Hispanic and Native North Americans), obesity, intrauterine environment, sex, and insulin resistance. Both secretion and action of insulin are usually disordered at clinical presentation, although one feature may predominate. Insulin resistance may manifest clinically with acanthosis nigricans (a velvety thickening of the dermis found especially on the posterior neck and axillae), features of polycystic ovarian syndrome (hyperandrogenism, menstrual irregularity) and features of the metabolic syndrome (hypertension, dyslipidaemia, and obesity).
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Expression pattern analysis of the putative
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