Welcome to Gaia! :: View User's Journal | Gaia Journals

Although TAM’s primary mechanism of action is believed to involve the inhibition of estrogen receptors (ERs), research over the years has indicated that additional nonER-mediated mechanisms exist [16]. TAM has been also used in the treatment of ER-negative cancers such as hepatocellular, pancreatic and renal carcinomas. Whether the inhibitory effects of TAM on QBC939 Imatinib Mesylate are ER-dependent or ER-independent needs to be further investigated.
In summary, TAM may be an effective anticancer agent against BDC because it can both inhibit growth and induce apoptosis effectively in QBC939 cells. Although the molecular mechanism for TAM-induced cancer cell apoptosis is pelvic girdle poorly understood, p53 and caspase-3 might be involved. These results provide experimental data for clinical use of TAM in treatment of BDC. TAM may offer a novel therapeutic strategy for BDC.
Acknowledgments
The present investigation was supported by the Medical Innovation Foundation of Fujian Province (2007-CXB-9), the Health Bureau Project of Xiamen (WSK0602) and the Program for Innovative Research Team in Science and Technology in Fujian Province University.