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Grey's Anatomy

"A Hard Day's Night"
Meredith Grey (Ellen Pompeo) enrolls in the surgical residency program at Seattle Grace Hospital, where she will spend the next 7 years. Hours into the program, Meredith discovers that a stranger she had a one-night-stand with is her new boss, Derek Shepherd (Patrick Dempsey). Preston Burke (Isaiah Washington), a cardiothoracic surgeon in the hospital begins to question his abilities, and decides to choose George (T.R. Knight) to perform the first operation, which earns him the nickname 007.

"The First Cut Is the Deepest"
Meredith looks for roommates to share her mother's house with, while tending to a rape victim and discovering an ailment with a newborn baby. Izzie (Katherine Heigl) helps out a Chinese woman whose daughter is in need, and Shepherd and Burke quarrel over the Chief of Surgery position.

"Winning a Battle, Losing the War"
Competition between the interns ensues after an annual unauthorized bike race causes many injuries. Izzie has trouble locating the family of a near brain-dead man, and Cristina (Sandra Oh) is excited when the patient's family agrees to harvest his organs if he dies, leading Bailey (Chandra Wilson) to lecture her on bedside manner. A patient who is a friend of Dr. Webber flirts with George.

"No Man's Land"
When a retired nurse at Seattle Grace is admitted, Cristina takes on her case and befriends her. A patient who recognizes Izzie from a modeling photo does not want her to treat him. Meredith and Shepherd treat a construction worker who surprisingly survived his injuries, but have bad news for his wife about his future. Alex (Justin Chambers) humiliates Izzie in front of everyone.

"Shake Your Groove Thing"
Izzie plans a party for her old boyfriend, while Meredith believes she may be in trouble when something goes wrong during a procedure. At the party, Bailey spots Shepherd and Meredith together. Cristina and Burke have sex in an on-call room.

"If Tomorrow Never Comes"
When Shepherd picks Meredith to assist in surgery on a patient with Parkinson's disease, Bailey thinks he is showing favoritism and is tough on Meredith. Alex befriends a patient who has a very large tumor, but when he talks about her behind her back, she requests he be removed from her case.

"The Self-Destruct Button"
Derek spends the night at Meredith's, which they try to keep secret from her other roommates. George suspects an anesthesiologist of drinking before major surgeries but is scolded when he does speak up. Alex treats a man who enjoys being in pain, and Cristina catches the flu.

"Save Me"
Alex treats a teenage Orthodox Jew who refuses surgery when she learns the treatment goes against her beliefs. Cristina has trouble relating to a pregnant woman who has terminal cancer and refuses to abort the baby, turning to Meredith for advice. Izzie is mesmerized by a patient who has psychic abilities, and is diagnosed with AVM.

"Who's Zoomin' Who?"
When a number of interns, including George, are diagnosed with STDs, Dr. Webber calls an emergency meeting. Izzie and Cristina want to perform an unauthorized autopsy against the family's wishes. Meredith is shocked when someone from Derek's past arrives at Seattle Grace.

"Raindrops Keep Falling On My Head"
Joe the bartender finds himself in the need of a very expensive standstill surgery that there is no way he'll be able to afford. Much to Meredith's discomfort, Addison requests her as her intern for the day. Still recovering from surgery, Dr. Webber asks George to be his "eyes and ears", but George finds it difficult to pass on any information. Cristina tells Meredith that she is pregnant without revealing the father. When Preston breaks off their relationship, she decides not to tell him either. Izzie and Alex's personal bond grows closer as he shows a more emotional side of himself.

"Enough is Enough"
Adele cuts her vacation short to come and care for Dr. Webber who is still recovering from surgery. Cristina and Meredith both express a great deal of bitterness toward their past doctoral flames. After having worked with nurse Olivia all day, George admits that he likes someone else. Alex and Izzie treat the victims from a car crash where the father needs a liver transplant, but his son doesn't want to donate because of the way his father abuses his mother. Bailey treats a man who has swallowed the heads of ten Judy dolls.

"Make Me Lose Control"
Ellis Grey is brought into the hospital for possible diverticulitis, and her Alzheimer's condition becomes known to everyone. George is assigned to her case, but she refuses him to treat her, thinking he's her ex-husband. Alex and Meredith treat a young patient with extreme blushing. Izzie stands up for her and Alex's blossoming friendship to the others. To Preston's shock, Cristina collapses in the O.R. and Addison has to remove her Fallopian tube, causing her baby to be aborted. Meredith tells Derek that hating him is exhausting and that she doesn't want to do it anymore.

"Deny, Deny, Deny"
Cristina is still recovering from her surgery while receiving a visit from her mother. Not wanting to rest in bed, she uninvited diagnoses Burke and Izzie's patient with Münchhausen's syndrome. Eager to seem fine, Cristina have refused to mourn all day, but in the end, she breaks down. Addison gives Derek divorce papers to sign, but he can't make up his mind. Alex asks Izzie on a date, but finding out that he hasn't passed an exam makes him unable to make the most of it. Bailey treats a longtime patient with cystic fibrosis to whom she's emotionally attached.

"Bring the Pain"
Meredith and Derek have to use more than medicine when a young Asian woman's traditionalist, religious father forbids her to have a life-saving operation unless a shaman is called upon to "retrieve her souls". Meanwhile, George and Alex are forced to perform surgery in a trapped elevator in an attempt to save a patient’s life in which George shows his potential while Alex shuns the challenge, and it is decision time for Derek and the two women in his life.

"Into You Like a Train"
As Meredith nervously awaits a final decision from Derek, her fear is interrupted when a train crash brings several seriously injured patients to the hospital. The doctors must make a tough decision in order to save at least one of them. Meredith understands that Derek has chosen Addison, and is crushed. Alex fails to notice a woman bleeding internally and she eventually dies from her injuries. As Addison and Izzie work with two pregnant women, Addison sees great potential in Izzie, who must decide whether her loyalty as Meredith’s friend outweighs professional gain.

"Something to Talk About"
Cristina, Izzie and Meredith aggressively pursue the case of Shane, a male patient who seems to have a hysterical pregnancy, which fascinates them and the entire medical staff, and also angers Meredith because everyone in the hospital is not respecting the privacy of the patients. In a parallel situation, many hospital workers whisper continuously about Derek and Meredith and give them little privacy as well. A sheltered young patient inspires Alex to better express his feelings for Izzie. The episode ends with Alex arriving at the bar, pulling Izzie backwards and kissing her.
Note: Kate Walsh billed as a series regular.


"Let It Be"
Derek and Addison Shepherd's professional relationship is challenged when their friends from Manhattan come to Seattle Grace seeking a radical, preemptive operation to avoid breast and ovarian cancer. Meanwhile, George can’t understand why a patient who fell five stories doesn’t seem happy to have survived and an elderly gentleman makes a difficult decision upon learning that his wife has only a few months to live. Cristina and Burke try to have a "normal" date, and Dr. Webber is disappointed by Bailey's fellowship decision -- until he learns her reasons: that she is pregnant.

"Thanks for the Memories"
The Thanksgiving holiday is more difficult for the interns and residents than any of them is willing to admit, as Izzie plans a big dinner. George endures the family tradition of hunting turkeys with his father and brothers. Having sneaked off to the hospital instead of helping Izzie out, Meredith treats a patient who's been in a vegetative state for 16 years. Burke helps Izzie to prepare the Thanksgiving meal. Just as Izzie is about to give up on anyone showing up for dinner, Alex, George and Cristina come back, while Meredith celebrates with a one-night-stand at Joe's bar.

"Much too Much"
Meredith is mortified when her one night stand shows up at the hospital suffering from priapism and needing medical attention. Izzie, Addison and Derek are assigned to a case where a woman carrying quintuplets is overwhelmed by numerous medical issues as she navigates her high-risk pregnancy. Alex’s shortcomings frustrate Izzie, especially when she catches Alex and Olivia having sex. On the other hand, Alex again shows his incompetence in treating one of his patients by administering the wrong dosage. Cristina reluctantly shows Preston where she lives.

"Owner of a Lonely Heart"
Cristina has little sympathy for Constance Ferguson, a prison inmate who jeopardizes her health just to get out of solitary confinement. The interns all keep careful watch on the family of premature quintuplets with a variety of serious health challenges. Izzie's anger at Alex reaches boiling point. Addison decides to teach Izzie a very painful lesson which she too once received from the chief, wanting Izzie to know the consequences of being too attached to her patients.

"Grandma Got Run Over By a Reindeer"
A young boy needs a heart transplant but doesn't seem to want it, and an argument over his treatment exposes major philosophical differences between Burke and Cristina. Meanwhile, when the interns rally to help Alex prepare to re-take his exam, Izzie feels betrayed and Meredith has to remind her of the true spirit of the Christmas holiday. Derek performs brain surgery on the patriarch of a mixed Jewish/Christian family who discuss celebrating Chrismukkah, but isn't in a festive mood despite a reconciliation with his wife.

"Begin the Begin"
Dr. Webber enforces an 80 hour per week maximum rule for the interns. Derek wants to enroll Ellis in a experimental treatment for Alzheimer's, but Meredith doesn't want his help and Derek needs Dr. Webber to intervene. Izzie seems to be getting over Alex when she shares an undeniable chemistry with Denny Duquette, a patient awaiting a heart transplant. Bailey goes to retrieve Denny's heart, taking Cristina along for the ride. Meanwhile George and Addison treat Bex, a young teen hermaphrodite.

"Tell Me Sweet Little Lies"
The truth is in short supply as Meredith and Cristina lie to each other about the status of their relationships. Cristina is angry with Derek since he has Meredith calling him McDreamy again. Cristina 'kinda' moves in with Burke. George is given the unpleasant task of discharging an elderly patient who refuses to leave the hospital despite no longer being sick. A competitive eater is presented with a tear in the lining of her esophagus. Alex is so nervous about the results of his exam that he eventually asks Izzie to open them for him.

"Break on Through"
Amidst a strike by the nurses, Meredith revives an elderly patient without knowing she's not supposed to. As the patient dies with her friends at her side, Meredith realizes she doesn't want her mother to die alone, and allows the chief to continue visit her, something she initially was upset with. Izzie treats a pregnant teenager with whom she has much in common, and her interfering upsets the patient's mother. Cristina is irritated with the perky new resident, Sydney, and asks for Burke's intervention when Sydney attempts a risky procedure to save a woman's infected leg from amputation.

"It's the End of the World"
Meredith has a feeling and George and Izzie have to call in Cristina to get her out of bed. A paramedic brings in a man with live ammunition in his chest; her hand is the only thing preventing an explosion. Bailey goes into labor and Derek and Cristina perform surgery on Bailey's husband who crashed the car on his way in. Izzie initiates things with Alex. When the anesthesiologist leaves the paramedic alone in the O.R., she panics and pulls her hand out of the patient - but Meredith takes her place.

"(As We Know It)"
Without her husband by her side, Bailey refuses to have the baby and George works with Addison to convince her to. Dr. Webber's stress causes an anxiety attack that brings Adele to the hospital. Meredith removes the explosive from the patient, but it explodes and kills Dylan. Preston and Derek overcome their initial rivalry and call each other by their first names. Cristina says "I love you too" to a sleeping Preston. Derek comes visiting Meredith after she nearly dies and Meredith tells him that she can't remember their last kiss.

"Yesterday"
Dr. Mark Sloan arrives in Seattle to try to convince Addison to continue their relationship, and is greeted with a punch from Derek, just for flirting with Meredith. Dr. Webber allows Sloan to assist Derek in a risky surgery to fix a teenage patient with facial tumors. Preston learns that Cristina still leases her apartment. Izzie treats a patient with spontaneous orgasms. Meredith goes to see her father for the first time in twenty years and is left unsatisfied with his answers about the past. George finally tells Meredith how he feels about her.
Note: First appearance of Eric Dane as Mark Sloan.

"What Have I Done to Deserve This?"
Following their sexual encounter, Meredith and George avoid each other at work, and George ends up falling down a stairwell and dislocating his shoulder. Frequent heart patient Denny is readmitted and grows closer to Izzie, causing Alex to be jealous. Although Bailey is on maternity leave, Addison asks for her treatment after her exposure and allergic reaction to poison oak. George moves in with Burke and Cristina and catches the eye of ortho resident Dr. Callie Torres.
Note: First appearance of Sara Ramirez as Callie Torres.

"Band-Aid Covers the Bullet Hole"
After Dr. Bailey is called into surgery, Cristina is forced to watch baby Tucker for the remainder of the day. Meanwhile, George and Meredith are still on the outs as she confides in Derek with her problem. Izzie continues to warm up to Denny who is having problems breathing. George and Callie further their flirtations over a teenaged patient who decides to chop off his own finger after Callie refuses to do it for him. Burke shows a preference for living with George over Cristina, and Addison gets a long-awaited admission from Derek that shows some hope for their marriage after all.

"Superstition"
When a series of deaths occur at Seattle Grace, the uncanny events bring out the doctors' superstitious sides. Four deaths in the morning implies that three more deaths are due for the day. This makes Izzie nervous about Denny's surgery, and a jealous Alex informs Denny of the likelihood of his death, prompting Izzie to completely end their relationship. Meanwhile, Derek and Addison discuss making a more permanent living arrangement, and Dr. Webber treats a former sponsor from his alcoholic's anonymous group. Izzie kisses Denny after he survives his surgery.

"The Name of the Game"
Bailey worries Dr. Webber is mommy-tracking her and becomes Derek's intern for the day. George begins a relationship with Callie and finds her living in the hospital. Meredith takes up knitting—and a vow of celibacy. Cristina competes with the Chief during classroom exercises. Burke tries to teach Alex a lesson about bedside manner, but it's a lesson that falls on deaf ears. Izzie tries to get George to move back into the house. George discovers that Addison's patient is Meredith's half-sister. Meredith meets Doc's vet, and takes a shine to him.

"Blues for Sister Someone"
Izzie grills George about the personal details of his life. Addison and Alex treat a pregnant woman who is expecting her seventh child, and face a difficult decision when the woman requests her tubes be tied off-record in order for her to avoid telling her very religious husband that she doesn't want to have any more children. Burke performs surgery on his musical hero who wants a pacemaker removed as it has ruined his ability to play the violin. Meredith learns from Denny that life is too short to follow the rules, and decides to abandon her knitting and accept a date with Doc's vet. George moves back in with Izzie and Meredith. Derek finally agrees to have hot sex with Addison.

"Damage Control"
A family is involved in a car accident caused by a surgical intern from another hospital. The young pregnant wife has massive injuries and eventually dies, though Alex performs a Caesarean section to save the baby. Derek is angry at Meredith after he sees her at the vet's. Burke is angry at Cristina after she fell asleep during sex the previous night. George does not stand up for Callie to his roommates and Denny is becoming angry at being stuck in bed with no end in sight.

"17 Seconds"
Part one of a three-part story arc.Gunshot victims from a nearby restaurant crowd Seattle Grace and the doctors are fully occupied. Knowing that Derek is mad at Meredith for dating Finn, Addison yells at him in the hallways, not realizing everyone can hear. Meredith asks Callie for advice on bone cancer in dogs. Burke is still angry at Cristina and chooses Alex over her to go with him to retrieve a heart for Denny. When Izzie finds out that Denny is about to not get the heart, she takes the matter in her own hands. As Burke races back to SGH to keep Izzie from doing something drastic, both Burke and Denny wind up in critical situations.
Note: First appearance of Brooke Smith as Erica Hahn.

"Deterioration of the Fight or Flight Response"
Part two of a three-part story arc.The interns help Izzie keep Denny alive after she's cut his Left ventricle assist device wire. Derek must perform surgery on Burke's shoulder and risk doing irreparable damage to the nerves. Cristina freezes in the O.R. during Burke's surgery. The chief discovers his niece's cancer has returned. Alex fights for Denny's heart at Mercy West, eventually offering Dr. Hahn the chance to scrub in at the surgery as Burke has been shot. Before surgery, Denny asks Izzie to marry him. However, after the heart has been inserted, it does not beat and back in Derek's OR, Burke still cannot move his fingers.

"Losing My Religion" Mark Tinker Shonda Rhimes May 15, 2006 22.60[33]
Part three of a three-part story arc.The interns are pulled into Dr. Webber's office for interrogation regarding the LVAD wire situation. None of them reveal the truth, protecting Izzie. Dr. Webber tells them all that they're off surgery, and they are to give his niece a prom. Burke finds a tremor in his right hand. Meredith and Derek make the decision to put Doc to sleep. Izzie accepts Denny's marriage proposal. During the prom, Derek and Meredith reunite in an exam room. The interns find Izzie lying in bed clinging to Denny, whose heart has stopped. Izzie leaves Seattle Grace, and on her way out confesses to Dr. Webber that she cut the LVAD wire and that she quits the program. Meredith remains torn on who she should follow: Derek or Finn.

"Time Has Come Today"
The doctors of Seattle Grace help Izzie cope with the loss of her fiancé, Denny, and her decision to quit the internship program. Meredith must decide what the future holds after her hospital liaison with Derek. The Chief is confronted by his wife, Adele (Loretta Devine), after spending the night in his office, and George seeks relationship advice from a surprising source.

"I Am a Tree"
Cristina meets Burke's parents, in the most awkward of circumstances; Izzie begins baking to comfort herself; Addison takes a break from her hospital duties and gets drunk; Richard discovers Callie living in the hospital; and a surgical patient lives what may be her last day to the fullest. Meredith makes a proposal to Derek and Finn.

"Sometimes a Fantasy"
Cristina tries to help Preston cope with his hand tremor, Izzie attempts to return to the hospital for the first time since she left the program, Alex deals with a patient who has a long history of injuries and believes she is a super hero, and George and Callie’s relationship moves forward. Meredith enjoys the benefits of her love triangle between her, Finn and Derek.

"What I Am"
As Addison works with Rebecca, a pregnant woman who needs to have a C-section but wants to give birth naturally, she begins to doubt her abilities as a doctor. The interns work with Shawn Sullivan, a car salesman who wants to return to his normal routine after he has surgery. However, when Shawn lights a cigarette that catches his face on fire, Derek and Mark argue over how they should proceed with his burn treatment. Meanwhile, Burke continues to rehab his injured hands with the help of Cristina, gradually progressing from operating on chickens to operating on a corpse. Meredith goes into surgery after her appendix bursts and after surgery, she finally makes a decision between Derek and Finn. Elsewhere, Callie and George continue to discuss their relationship and Izzie meets a man who gives her the surprise of her life.

"Oh, the Guilt"
Bailey treats a young mother battling breast cancer, Derek learns more about Mark and Addison's relationship, the interns defend a resident's competence at a hospital staff meeting, and Meredith and Addison examine a couple who find themselves in a rather awkward position.

"Let the Angels Commit"
Cristina scrubs in on the rare "humpty dumpty" procedure, much to the envy of her fellow doctors, Alex questions his future medical specialty, George and Addison work with a pregnant woman with an unusual dilemma, and Derek receives a surprise visit from his sister. Meredith becomes Izzie's boss and the two treat a patient that may be admitted into psychiatry.

"Where the Boys Are"
The men of Seattle Grace go on a camping trip together, Addison and Callie must team up to work on a patient, Meredith assist Sloan with a procedure unlike any she has experienced, and, suspicious of her recent actions at the hospital, Bailey confronts Cristina.

"Staring at the Sun"
The O'Malley Family visits George at the hospital, Meredith is determined to have a more positive outlook on life, Derek and Addison strive for a civil relationship, and Richard endeavors to reunite with his wife, Adele.

"From a Whisper to a Scream"
A traumatic car accident fills the ER, Cristina has a crisis of conscience about her deceptive teamwork with Burke, and Izzie pushes the boundaries of her probation.

"Don't Stand So Close to Me"
Recent events strain Burke and Cristina's relationship, Meredith's half-sister, Molly, is admitted to the hospital, and Derek and Mark must work together when two close-knit brothers seek medical help. Meredith has to tell some bad news to her mom and is shocked when something happens.

"Six Days (Part 1)"
Part one of a two-part episode. After a successful operation on his heart, George's father undergoes surgery for his cancer, Thatcher Grey visits Seattle Grace in order to see his new granddaughter, and Meredith discovers that Derek has trouble sleeping soundly.

"Six Days (Part 2)"
Part two of a two-part episode. George and his family must struggle with a difficult decision regarding Harold who is on life support. Meredith learns she shares something in common with her father. Addison regrets an event from her past. Izzie is barred from Heather's surgery after Bailey finds out she paid for the operation.

"Great Expectations"
After the Chief announces his retirement, rumors begin to circulate on his departure and successor. Dr. Bailey is ambitious to create a free medical clinic. Two people at the hospital receive an unexpected proposal.

"Wishin' and Hopin'"
The race for the Chief's position is on, as the doctors compete for Richard's affections, a surgical patient endangers the lives of those around her, and Meredith's Alzheimer's-stricken mother, Ellis, experiences a change in her medical condition.

"Walk on Water"
Part one of a three-part story arc. A mass trauma situation challenges the interns in many different ways. Richard begins a transition while going through a life change, while Cristina struggles to tell Meredith and the others about becoming engaged to Burke. At the end Meredith is drowning...

"Drowning on Dry Land"
Part two of a three-part story arc. Meredith is still under water, which no one realizes until Derek finds her coat. Izzie drills holes into the head of a trauma patient who is experiencing seizures. George continues to look for a patient's lost son after providing her with false optimism. Alex finds no hope in searching for the pregnant Jane Doe's family as she undergoes surgery. Meredith is taken to the hospital, with the doctors trying to save her life as she wakes up dead.

"Some Kind of Miracle"
Part three of a three-part story arc. The interns of Seattle Grace take vigil outside Meredith's hospital room as Bailey and the Chief struggle to revive her. Meanwhile, Meredith is in limbo where she meets up with Denny, Dylan and many other familiar deceased patients from the past. Cristina remedies her grief for Meredith by shopping and Alex continues to bond with the pregnant Jane Doe who remains unclaimed. Ellis Grey goes into cardiac arrest. Meredith finally wakes up, to see everyone who love her by her side.

"Scars and Souvenirs"
The race for chief heats up after a new competitor enters the fray, tensions escalate between Izzie and George, and Callie must reveal a big secret. Meanwhile, Derek treats a patient near and dear to him, while Alex continues his work with Jane Doe. Meredith receives Alex in her house and she and "her" family have a dinner. Izzie wakes up, realizing that she has hooked up with someone that she never expects.

"My Favorite Mistake"
George meets his new father-in-law (Hector Elizondo) (and is in no condition to make a good impression), Alex helps Jane Doe determine how the world will see her from now on, the hospital board begins interviewing the candidates for the Chief's position, and Izzie wrestles with a startling revelation. Mark takes Meredith as his intern, only to impress the chief, something that Derek doesn't like.

"Time After Time"
When Izzie's daughter is brought to the hospital for leukemia treatment, Izzie is asked to donate her bone marrow in support. Derek finds that Meredith stands in his way of becoming chief. Marlowe continues to intrude on Burke and Cristina's lives with an impending surgery Burke will perform. Meredith becomes closer to her stepmother (Mare Winningham). Parents claiming to be Ava's come in to identify her but learn she is not theirs.

"Desire"
As the interns of Seattle Grace cram for their upcoming exam, the attendings vie for the Chief's position by tending to the chairman of the hospital board (Mitch Pileggi) after he is admitted as a patient. Meanwhile, Burke struggles to involve Cristina in the wedding planning, things heat up between Addison and Alex, and Derek questions his relationship with Meredith.

"The Other Side of This Life (Part 1)"
Part one of a two-hour episode. After things become too complicated in Seattle, Addison travels to Los Angeles to reunite with old friends from medical school. Meanwhile, Derek must perform emergency surgery on Ava/Jane Doe (Elizabeth Reaser), Meredith's family is back in the hospital, and Cristina plans her wedding with both her mother and Burke's mother. This double episode is a backdoor pilot for Private Practice.

"The Other Side of This Life (Part 2)"
Part two of a two-hour episode. After things become too complicated in Seattle, Addison travels to Los Angeles to reunite with old friends from medical school. Meanwhile, Derek must perform emergency surgery on Ava/Jane Doe and Cristina plans her wedding with both her mother and Burke's. George and Izzie kiss and Meredith's bond to her family ends with an unexpected death. This double episode is a backdoor pilot for Private Practice.

"Testing 1-2-3"
The interns take the biggest test of their careers, their first-year medical exams, as the residents attend to three injured mountain climbers. Meanwhile Callie’s suspicions of George and Izzie grow, and Cristina struggles to write her wedding vows. Meredith is still feeling guilty about her stepmom's death and is unable to do the test, as she needs help that she doesn't want.

"Didn't We Almost Have It All?"
Cristina and Burke’s wedding day arrives. Along with the interns’ first exam results, a successor to the Chief is named. Callie and George make a big decision about their relationship. Meredith and Derek call their relationship "Over?".

Pit Bull Kisses
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Pit Bull Kisses
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